摘要
目的探讨血清癌胚抗原(CEA)、糖类抗原(CA)724和CA199联合检测对胃癌的诊断价值。方法应用电化学发光法对胃癌患者95例、胃良性病变患者63例、健康对照者101例进行血清CEA、CA199及CA724三项肿瘤标志物的检测。结果胃癌组CEA、CA199、CA724单项检测水平及阳性率均显著高于健康对照组,差异有统计学意义(P<0.05),CEA、CA724单项检测水平及阳性率也明显高于胃良性病变组,差异有统计学意义(P<0.05),胃癌组CA199单项检测水平及阳性率与胃良性病变组比较差异无统计学意义(P>0.05),3项肿瘤标志物联合检测的敏感度最高,高于2项联合检测及单项检测。结论联合检测3种肿瘤标志物有助于提高胃癌诊断的敏感性,对胃癌的辅助诊断具有临床价值。
Objective To investigate the diagnostic value of combined detection of serum carcinoembryonic antigen （CEA）,car-bohydrate antigen 199 （CA199）and carbohydrate antigen 724 （CA724）for the diagnosis of gastric cancer.Methods Plasma levels of CEA,CA199 and CA724 were detected by using electrochemiluminescence in 95 patients with gastric cancer,63 patients with be-nign gastric diseases and 101 healthy subjects.Results Levels and positive rates of CEA,CA199 and CA724 in gastric cancer group were significantly higher than healthy control group （P〈0.05）.Levels and positive rates of CEA and CA724 in gastric cancer group were significantly higher than benign gastric diseases group （P〈0.05）.There was no statistically significant difference of level and positive rate of CA199 between gastric cancer group and benign gastric diseases group（P〉0.05）.The sensitivity of com-bined detection was obviously higher than any single detection or combined detection of two indexesConclusion Combined detection of the three tumor markers could improve the diagnostic sensitivity and coincidence rate,which have practical diagnostic value for gastric cancer.
出处
《国际检验医学杂志》
CAS
2014年第12期1545-1546,1549,共3页
International Journal of Laboratory Medicine
