摘要
目的:比较培菲康联合三联疗法和含铋剂四联疗法治疗幽门螺旋杆菌(Helicobacter pylori,H.pylori)阳性消化性溃疡的疗效.方法:纳入150例H.pylori阳性消化性溃疡患者,随机分为3组,A组给予雷贝拉唑、阿莫西林、克拉霉素治疗;B组给予雷贝拉唑、阿莫西林、克拉霉素、胶体果胶铋胶囊治疗;C组给予雷贝拉唑、阿莫西林、克拉霉素、培菲康治疗.观察各组H.pylori根除率、药物不良反应发生率和溃疡愈合率.结果:H.pylori根除率B组(90%)和C组(88%)高于A组(72%),差异有统计学意义(P<0.05);B(90%)组高于C组(88%),但差异无统计学意义(P>0.05).不良反应发生率A组(30%)和B组(32%)高于C组(10%),差异有统计学意义(P<0.05);B组(32%)高于A组(30%),但差异无统计学意义(P>0.05).溃疡愈合率B组(88%)>C组(84%)>A组(78%),但差异无统计学意义(P>0.05).结论:培菲康联合三联疗法治疗H.pylori阳性消化性溃疡的疗效肯定,不良反应小,临床症状缓解显著,溃疡愈合率高,值得临床推广.
AIM： To compare the efficacy and safety of Bifico combined with triple therapy vs bismuth con- taining quadruple therapy in the management of Helicobacter pylori （H. pylori） positive peptic ulcer. METHODS： One hundred and fifty patients with H. pylori positive peptic ulcer were randomly divided into three groups： A, B and C. Group A was treated with rabeprazole, amoxicillin, and clarithromycin, group B was treated with rabe- prazole, amoxicillin, clarithromycin, and col- loidal bismuth pectin, and group C was treated with rabeprazole, amoxicillin, clarithromycin, and Bifico. The rate of H. pylori eradication, the incidence of adverse reactions and ulcer healing rate were compared between the three groups. RESULTS： The rate of H. pylori eradication in groups B （90%） and C （88%） was significantly higher than that in group A （72%） （P 〈 0.05）, but there was no significant difference between groups B and C （P 〉 0.05）. The incidence of ad- verse reactions in groups A （30%） and B （32%） was significantly higher than that in group C （10%） （P 〈 0.05）, but there was no significant difference between groups A and B （P 〉 0.05）. The ulcer healing rate showed no significant dif- ference among the three groups （group B： 88%; group C： 84%; group A： 78%; P 〉 0.05）. CONCLUSION： Bifico combined with triple therapy is effective in the treatment of H. pylori positive peptic ulcer, with less adverse reactions and higher ulcer healing rate.
出处
《世界华人消化杂志》
CAS
北大核心
2014年第21期3174-3177,共4页
World Chinese Journal of Digestology
