摘要
克罗恩病是一种主要累及消化道的自身免疫相关的炎症性疾病.近年来,该病的发病率和患病率在亚洲地区急剧上升,而结直肠癌是其严重的并发症之一.因此,了解克罗恩病癌变的现状与机制,加强对患者的癌症筛查与监测,对于降低克罗恩病患者的癌症病死率具有重要意义.本文对克罗恩病并发结直肠癌的倾向和分子机制,以及目前国际上对克罗恩病患者结直肠癌预防的研究进展进行综述.
Crohn’s disease is a relapsing systemic inflammatory disease mainly affecting the gastrointestinal tract.Recently,the incidence and prevalence of Crohn＇s disease is increasing dramatically in Asia,and colorectal cancer is one of the most fatal complications of Crohn’s disease.A thorough understanding of the carcinogenesis of Crohn’ s disease and enhance the surveillance of colorectal cancer among Crohn’s disease is therefore of significant importance to reduce the mortality.In this review,the tendency and molecular mechanism of carcinogenesis of Crohn＇s disease were discussed,and the present research on the prevention against colorectal cancer in patients with Crohn’s disease was introduced.
出处
《中华消化外科杂志》
CAS
CSCD
北大核心
2014年第8期662-665,共4页
Chinese Journal of Digestive Surgery
基金
国家自然科学基金（81270478）
关键词
克罗恩病
炎症性肠病
炎症
结直肠肿瘤
Crohn’s disease
Inflammatory bowel disease
Inflammation
Colorectal neoplasms
