摘要
目的探讨轻度认知功能障碍(MCI)患者与认知功能正常的老年人大脑脑血流参数rCBFivim的差异,评估磁共振体素内不相干运动(IVIM)在MCI诊断中的价值。方法选择2012年7月至2013年5月在山东大学附属千佛山医院神经内科就诊的主诉记忆力减退的患者,分为MCI组和认知正常组(NC组),各20例。进行IVIM扫描,测量双侧额叶、顶叶、颞叶、枕叶和海马区D*和f值,计算rCBFivim值,比较MCI组和NC组的差异。结果 MCI组双侧颞叶、顶叶、额叶、双侧海马区rCBFivim值较NC组降低(P均<0.05);小脑、枕叶rCBFivim值较NC组降低,但差异无统计学意义(P均>0.05)。结论 IVIM对MCI有一定的诊断意义,可作为评估MCI患者脑血流量呈下降的有效方法。
Objective To investigate the difference of rCBFivimbetween the aged people who suffered from mild cognitive impairment（ MCI） and who showed normal cognition,and to evaluate the value of the intravoxel incoherent motion（ IVIM） in the diagnosis of MCI. Methods The patients who visited the Neurology Department of Qianfoshan Hospital Affiliated to Shandong University from July 2012 to May 2013 with complaints of memory loss were enrolled in this study. Twenty MCI patients（ MCI group） and 20 individuals with normal cognition（ NC group） were performed IVIM detection. The values of D^＊and f were measured in the areas of both sides of frontal,parietal,occipital lobe,temporal lobe and hippocampus,followed by the calculation of rCBFivim. Results Compared with NC group,rCBFivimsignificantly decreased in the frontal,parietal,temporal lobe and the area of hippocampus in MCI group（ all P〈0. 05）.Compared with NC group,rCBFivimof MCI group also decreased in the cerebellum and occipital lobe,which showed no statistical difference（ all P〉0. 05）. Conclusion The intravoxel incoherent motion technique is helpful for the diagnosis of MCI,and it is an useful tool for the assessment of cerebral blood flow in patients with MCI.
出处
《山东大学学报（医学版）》
CAS
北大核心
2014年第8期68-71,共4页
Journal of Shandong University:Health Sciences
基金
山东省科技发展计划攻关项目(2009GG10002024)
山东省医药卫生科技发展计划项目(2009HW075)
关键词
轻度认知功能障碍
体素内不相干运动
磁共振灌注成像
Mild cognitive impairment
Intravoxel incoherent motion
Magnetic resonance perfusion imaging
