摘要
中医药治疗骨性关节炎(osteoarthritis,OA)具有较大的潜力与优势,疗效确切、价格低廉、使用方便,克服了西药价格昂贵、副作用大、难以长期服用、依从性较差、治疗效果不佳的特点,开发应用前景广阔,但其具体作用机制尚不完全明确。本文通过对近五年的中医药治疗骨性关节炎作用机制研究相关文献的整理,从细胞因子、氧自由基、基质金属蛋白酶及炎症介质等相关因子、信号转导通路、软骨细胞凋亡、软骨下骨重塑等多方面概述了中医药治疗OA作用机制的研究进展。
Treating osteoarthritis with traditional Chinese medicine has a large potential and advan-tages such as low cost and curative effect,and convenience. It overcomes the weaknesses of taking western medicine such as high cost, big side effect, difficulty of taking for long time, poor complicance, etc. . Therefore,treating osteoarthritis with traditional chiense medicine has bright prospect for the development and application,but the mechanism of action is still not completely clear. This paper sorted out the litera-tures in recent five years,which summarized the related factors like cytokines, oxygen free radicals,matrix metallo proteinase and cytokines, signal transduction pathway, cartilage cells apoptosis. The subchondral bone restore such as studied the mechanism of action in treating osteoarthritis with traditional Chinese medi-cine.
出处
《环球中医药》
CAS
2014年第8期656-660,共5页
Global Traditional Chinese Medicine
基金
国家级大学生创新创业训练计划(201310572028)
关键词
骨性关节炎
中医药疗法
作用机制
Osteoarthritis
Chinese medicine therapy
Mechanism of action
