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P2Y12基因多态性与氯吡格雷抵抗的相关性研究 被引量：3

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摘要 目的:为临床合理应用氯吡格雷提供参考。方法:检索近年来关于P2Y12基因多态性与氯吡格雷抵抗的相关性研究文献,进行归纳、总结。结果与结论:P2Y12受体C34T、G52T、i-T744c位点的基因多态性是否会影响氯吡格雷的抗血小板治疗效果,诱发氯吡格雷抵抗,并使得患者的主要心血管不良事件的发生风险增加,以及CYP2C19基因多态性的存在是否会与P2Y12基因多态性共同影响氯吡格雷的抗血小板治疗效果,目前的研究尚无统一的定论,还需要更多的前瞻性研究来揭示。
作者 刘利龙 宋佳 吴禹蒙 吴玉波
机构地区 哈尔滨医科大学附属第四医院药学部
出处 《中国药房》 CAS CSCD 2014年第32期3065-3068,共4页 China Pharmacy
关键词 P2Y12 基因多态性 氯吡格雷抵抗 抗血小板治疗
分类号 R968 [医药卫生—药理学] R973.2 [医药卫生—药品]
  • 相关文献

参考文献6

二级参考文献73

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共引文献55

同被引文献26

  • 1吴小利,李健,王成彬.氯吡格雷抵抗患者的血小板功能的实验室监测和遗传基因多态性的研究进展[J].临床检验杂志（电子版）,2014,3(2):595-602. 被引量：2
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  • 10孙春喜,任澎.基因多态性与阿司匹林和氯吡格雷抵抗相关性的研究进展[J].医学综述,2012,18(20):3356-3358. 被引量：6

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中国药房
2014年 第32期

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