摘要
目的:观察前列地尔、银杏达莫联合高压氧治疗突发性耳聋的临床疗效及安全性。方法:将100例突发性耳聋患者按随机数字表法均分为对照组和试验组。对照组患者给予地塞米松磷酸钠注射液10 mg,加入5%葡萄糖注射液500 ml中,静脉滴注,qd,连用3 d后剂量减少为5 mg,加入5%葡萄糖注射液250 ml中,静脉滴注,qd,连用5 d后停药;三磷酸腺苷辅酶胰岛素20 mg,加入5%葡萄糖注射液500 ml中,静脉滴注,qd;前列地尔注射液10μg,加入0.9%氯化钠注射液100 ml中,静脉滴注,qd;银杏达莫注射液30 ml,加入0.9%氯化钠注射液500 ml中,静脉滴注,qd。试验组患者在对照组治疗的基础上进行高压氧治疗,患者入舱后加压20 min至舱内压力为0.25 MPa,面罩吸氧60 min,减压20 min出舱,qd。两组患者疗程均为14 d。观察两组患者的临床疗效、治疗前后血液流变学指标及不良反应发生情况。结果:试验组患者总有效率显著高于对照组,两组比较差异有统计学意义(P<0.05)。治疗前两组患者血液流变学指标比较,差异均无统计学意义(P>0.05);治疗后两组患者血液流变学指标均显著低于同组治疗前,且试验组低于对照组,差异有统计学意义(P<0.05)。两组患者治疗期间均未见明显不良反应发生。结论:前列地尔、银杏达莫联合高压氧治疗突发性耳聋较未用高压氧更能有效改善患者的血液流变学特征,改善微循环,疗效显著,且安全性较好。
OBJECTIVE： To observe the efficacy and safety of alprostadil and yinxing damo combined with hyperbaric oxygen in the treatment of sudden hearing loss. METHODS： 100 patients with sudden hearing loss were randomly divided into control group and trial group. Control group was given Dexamethasone sodium phosphate injection 10 mg added into 5% glucose 500 ml intravenously, qd, 3 d later decreasing to 5 mg added into 5% glucose 250 ml intravenously, qd, and the stopped taking medicine after 5 d consecutive medication; ATP coenzyme A and insulin 20 mg added into 5% Glucose injection 500 ml intravenously, qd; Alprostadil injection 10 gg added into 0.9% Sodium chloride injection 100 ml intravenously, qd; Yinxing damo injection 30 ml added into 0.9% Sodium chloride injection 500 ml intravenously, qd. Trial group received hyperbaric oxygen therapy based on control group, as pressurizing for 20 rain to 0.25 Mpa, oxygen intake via mask for 60 rain after entering hyperbaric chamber, and then leaving the chamber after decompressing for 20 min. Treatment course of 2 groups lasted for 14 d. Clinical efficacies of 2 groups were observed, and hemorheology index and ADR were observed before and after treatment. RESULTS： Total effective rate of trial group was significantly higher than that of control group; there was statistical significance （P〈0.05）. There was no statisti- cal significance in hemorheology index between 2 groups before treatment （P〉0.05）. After treatment, hemorheology index of 2 groups was significantly lower than before, and that of trial group was lower than that of control group; there was statistical signifi- cance （P〈0.05）. No significant ADR was found in 2 groups during treatment. CONCLUSIONS： It is significantly effective and safe to treat sudden hearing loss with hyperbaric oxygen combined with alprostadil and yirlxing damo, which also can improve hemorhe- ology characteristics and microcirculation.
出处
《中国药房》
CAS
CSCD
2014年第32期3007-3009,共3页
China Pharmacy
关键词
高压氧
前列地尔
银杏达莫
突发性耳聋
疗效
安全性
Hyperbaric oxygen
Alprostadil
Yinxing damo
Sudden heating loss
Therapeutic efficacy
Safety
