摘要
目的 探讨血府逐瘀汤联合美托洛尔治疗老年人冠心病心绞痛的疗效及对患者血浆同型半胱氨酸和血脂水平的影响.方法 80例老年冠心病心绞痛患者,按随机数字表法分为两组各40例,研究组使用血府逐瘀汤联合美托洛尔进行治疗,对照组采用西药常规治疗,比较两组患者临床疗效及治疗前后血浆同型半胱氨酸（HCY）、血脂水平变化.结果 研究组患者治疗有效率为92.5％,明显高于对照组的65％（x2=4.58,P＜0.05）;研究组治疗后血浆HCY为（15.8±3.7）μmol/L,低于对照组的（26.5±10.3） μmol/L（t=6.18,P＜0.05）;研究组患者经治疗后血清中LDL、HDL、TC、TG水平较干预治疗前均明显改善（t=9.82、7.66、7.89、6.54,均P＜0.05）,且改善程度较对照组明显（t=8.35、7.67、7.82、6.33,均P＜0.05）.结论 血府逐瘀汤联合美托洛尔治疗老年人冠心病心绞痛疗效明显优于单纯西药治疗,值得临床推广应用.
Objective To observe the effect of Xuefu Zhuyu Decoction combined with metoprolol in the treatment of senile coronary heart disease and angina pectoris and its influence on the level of blood lipid and HCY in plasma.Methods 80 cases of elderly patients with coronary heart disease and angina were randomly divided into the two groups of 40 cases according to the random number table method.The study group was treated with Xuefu Zhuyu Decoction combined with metoprolol,while the control group only used conventional western medicine for treatment,the efficacy and changes of plasma homocysteine （HCY） and serum lipid levels before and after treatment of two groups were compared.Results The effective rate of patients in the study group was 92.5 ％,significantly higher than 65％ of the control group （x2 =4.58,P ＜0.05） ;The plasma HCY of the study group after treatment was （15.8 ±3.7） μmol/L,significantly lower than （26.5 ± 10.3） μmol/L of the control group （t =6.18,P ＜0.05） ;The levels of serum LDL,TC,TG and HDL of the study group after treatment were significantly improved than before treatment （t =9.82,7.66,7.89,6.54,all P ＜ 0.05）,and it improved significantly than that of the control group （t =8.35,7.67,7.82,6.33,all P ＜ 0.05）.Conclusion Xuefu Zhuyu Decoction combined with metoprolol has a better effect than the pure western medicine in treatment of senile coronary heart disease and angina pectoris,which is worthy of clinical application.
出处
《中国基层医药》
CAS
2014年第18期2783-2785,共3页
Chinese Journal of Primary Medicine and Pharmacy
关键词
血府逐瘀汤
美托洛尔
冠心病
心绞痛
Xuefu Zhuyu Decoction
metoprolol
coronary heart disease
angina pectoris
