摘要
目的 通过对卵巢癌患者术后单纯淋巴结区域复发病例进行回顾性分析,以探讨其治疗和生存情况,并探讨影响其预后的因素.方法 收集该院近8年卵巢癌患者1 348例,筛选出术后单纯淋巴结区域复发病例44例,通过完整的病史分析,获得其复发特征、治疗、预后和预后影响因素.结果 44例患者根据病情采用二次手术、放疗或化疗,治疗后病情完全缓解36例,部分好转7例,1例无明显改善.44例患者5年累积生存率65.32％,淋巴结清扫术辅助化疗组,局部放、化疗组,单纯化疗组累积生存率差异有统计学意义（Kaplan-Meierx2=23.685,P=0.000）;对可能影响预后的各因素行单因素Log-rank分析发现,年龄、复发时间、复发灶数目与预后密切相关（x2=11.254、9.254、15.625,均P＜0.05）;Cox回归分析发现,年龄、复发时间、复发灶数目是影响预后的独立因素（P=0.000、0.006、0.000）.结论 卵巢癌患者术后单纯淋巴结区域复发有其独特特点,治疗应考虑影响其预后因素进行.
Objective To explore effects,survival and prognostic factors of regional lymph node recurrence of ovarian cancer patients after surgery in our hospital.Methods 1 348 cases of ovarian cancer in our hospital,regional lymph nodes filter out the postoperative recurrence alone were selected,44 cases were analyzed through a complete medical history,then the recurrence characteristics,treatment,prognosis,and prognostic factors were obtained.Results According to the disease,44 patients were treated with the second surgery,radiotherapy or chemotherapy,completed remission after treatment in 36 cases,some improvement in 7 cases,1 case,no significant improvement.44 patients 5-year cumulative survival rate was 65.32％,lymph node dissection adjuvant chemotherapy group,local radiotherapy and chemotherapy group,chemotherapy group cumulative survival difference were statistically significant （Kaplan-Meierx2 =23.685,P =0.000）;may affect prognostic factors univariate Log-rank analysis showed that age,the recurrence time,the number of tumor recurrence and prognosis （x2 =11.254,9.254,15.625,all P ＜ 0.05） ; Cox regression analysis showed that age,time to recurrence,relapse foci were independent prognostic factors （P =0.000,0.006,0.000）.Conclusion The patients with ovarian cancer recurrence after surgery alone has its unique regional lymph node characteristics,treatment should consider the factors affecting the prognosis.
出处
《中国基层医药》
CAS
2014年第18期2771-2773,共3页
Chinese Journal of Primary Medicine and Pharmacy
关键词
卵巢癌
复发
淋巴结区域
预后
Ovarian cancer
Recurrence, mere regional lymph node
Prognosis
