摘要
动脉粥样硬化是一种慢性炎症性疾病,血小板和淋巴细胞参与其发生、发展的整个过程。血小板和淋巴细胞之间通过直接接触和分泌可溶性介质的方式发生相互作用,进而调节彼此功能,并可形成细胞间聚集体,同时血小板还可促进淋巴细胞在损伤血管壁的募集。血小板-淋巴细胞相互作用影响动脉粥样硬化的进展,有可能成为新的治疗靶点。本文主要针对血小板-淋巴细胞的相互作用及其对动脉粥样硬化的影响进行综述。
Atherosclerosis is a chronic inflammatory disease. Platelets and lymphocytes are involved in the progress of atherosclerosis. Platelets can interact with lymphocytes via direct contact or release soluble mediators and regulate the function of lymphocyte, even form ＂platelet-lymphocyte＂ aggregates, and subsequently promote the recruitment of lymphocyte into the injured vessel wall. Platelet-lymphocyte interaction influences the development of atherosclerosis and may be a promising therapeutic target. This review will focus on the platelet-lymphocyte interaction and its relationship with atherosclerosis.
出处
《中国动脉硬化杂志》
CAS
CSCD
北大核心
2014年第8期853-858,共6页
Chinese Journal of Arteriosclerosis
基金
国家自然科学基金(NSFC81270362)
国家重大新药创制课题(2013ZX09103003-001)
