摘要
目的探讨以莫西沙星为主的三联疗法(莫西沙星+雷贝拉唑钠肠溶片+阿莫西林)和常规四联疗法(雷贝拉唑钠肠溶片+胶体果胶铋+克拉霉素+甲硝唑)治疗幽门螺杆菌(H.pylori)感染首次根除失败患者中的有效性与安全性。方法选取2010年1月-2013年1月110例以质子泵抑制药为基础的三联疗法根除H.pylori失败的患者为研究对象,随机分为观察组和对照组各55例,观察组患者采用以莫西沙星为主的三联疗法,对照组患者采用常规四联疗法,两组均治疗7 d,4周后复查14C-呼气试验,比较两组H.pylori根除率、不良反应发生率及胃黏膜炎症情况。结果观察组H.pylori根除率为90.9%,明显高于对照组的69.1%,差异有统计学意义(P<0.05);观察组不良反应发生率为10.9%,显著低于对照组的32.7%,差异有统计学意义(P<0.05);两组在治疗后胃黏膜炎症均得到明显改善,且观察组改善程度显著优于对照组,差异有统计学意义(P<0.05)。结论以莫西沙星为主的三联疗法与常规四联疗法相比,H.pylori根除率高,不良反应率低,可显著改善胃黏膜炎症情况,疗效好且安全性高,值得在临床推广应用。
Objective To investigate of the efficacy and safety of the triple therapy （Moxifloxacin ＋ Rabeprazole Sodium Enteric-coated Tablets ＋ Amoxicillin） which was given priority to use Moxifloxacin and the routine quadruple therapy （Rabeprazole Sodium Enteric-coated Tablets ＋ Colloidal Bismuth Pectin ＋ Clarithromycin ＋ Metronidazole） in treatment of patients with failure of eradication of Helicobacter pylori （H.pylori） infection for the first time.Methods One hundred and ten cases of failure of eradication of H.pylori infection for the first time patients with the triple therapy,which based on proton pump inhibitor from Jan.2010 to Jan.2013 were selected as the research objects,randomly divided into the observation group and the control group with 55 cases in each group,patients in observation group were treated by the triple therapy,while patients in control group were treated by the routine quadruple therapy,patients in two groups were both treated for 7 d.14C-breath test was reviewed after 4 weeks,the eradication rate of H.pylori,incidence of adverse reactions and gastric mucosal inflammation of patients in two groups were compared.Results The eradication rate of H.pylori in observation group was 90.9％,it was significantly higher than that in control group （69.1％）.The incidence of adverse reactions in observation group was 10.9％,it was significantly less than that in control group （32.7％）.The gastric mucosa inflammation of patients in two groups were both obviously improved after treatment,and the improved degree in observation group was significantly better than that in control group.Conclusion Compared with the routine quadruple therapy,the H.pylori eradication rate of the triple therapy which is given priority to use Moxifloxacin is higher,the incidence of adverse reaction is lower,it can significantly improve the gastric mucosa inflammation,it has a good curative effect and a high security,it is worth popularizing in clinical application.
出处
《胃肠病学和肝病学杂志》
CAS
2014年第7期752-754,共3页
Chinese Journal of Gastroenterology and Hepatology
关键词
幽门螺杆菌
常规四联疗法
莫西沙星
疗效
不良反应
Helicobacter pylori
Routine quadruple therapy
Moxifloxacin
Curative effect
Adverse reactions
