摘要
目的:探讨乳腺癌组织中SOX4的表达变化,并探讨其临床意义。方法 :采用免疫组化方法对正常乳腺组织及原发乳腺癌组织中的SOX4蛋白进行检测,分析其表达水平与乳腺癌患者临床病理特征间的关系。结果:SOX4在乳腺癌组织中的表达水平显著高于正常乳腺组织(P<0.01),与乳腺癌组织ER、PR表达、淋巴结转移有相关性(P<0.01、P<0.05、P<0.01);SOX4的表达与Her-2、EGFR表达、肿瘤组织学分级、患者年龄、肿瘤大小无关(P>0.05)。结论:SOX4在乳腺癌组织中高表达,与淋巴结的转移有关,可能成为乳腺癌发生发展的预测指标之一。
Objective：To oberserve the changes of SOX4 protein in breast cancer and investigate the clinical significance.Methods：The expression level of SOX4 in breast cancer cases were detected by means of immunohistochemistry and the relationship between SOX4 and other clinicopathologic factors were analyzed.Results：The expression levels of SOX4 in breast cancer tissues were significantly higher than those in normalbreast tissues （P＜0.01）.High expression of SOX4 in breast cancer tissues was associated with ER、PR、lymph node involvement （P＜0.05）,but not with age,tumor size and histological tumor grade （P＞0.05）.Conclusion：SOX4 protein,highly expressed in breast cancer,is related to the metastasis of the breast cancer and might be a valuable marker for the carcinogenesis and progression of the breast cancer.
出处
《中国现代普通外科进展》
CAS
2014年第6期459-461,共3页
Chinese Journal of Current Advances in General Surgery
关键词
乳腺肿瘤
SOX4
免疫组织化学
Breast neoplasms
Sry-related high-mobility-group box
Immunohistochemistry
