摘要
目的探讨无功能性阑尾神经内分泌肿瘤的临床病理特点,免疫表型及预后。方法回顾性分析13例无功能性阑尾神经内分泌肿瘤的临床病理资料,对肿瘤进行光镜观察,并做免疫组化。结果无功能性阑尾神经内分泌肿瘤可分为4个临床病理分级,其病理学特点,生物学行为及预后均有不同。本组病例中无功能性阑尾神经内分泌肿瘤G1 8例,G2 3例,G3或神经内分泌癌2例,免疫组化检查AE1/AE3阳性3例,Syn阳性11例,CgA阳性10例。随访期内三个级别5年生存率分别为100%,100%,51%。结论无功能性阑尾神经内分泌肿瘤病理分级及临床分期与预后密切相关,对其治疗有指导作用,免疫组化合理应用可提高神经内分泌肿瘤的诊断率,减少临床误诊,避免过度治疗。
Objective To investigate the clinical and pathological characteristics of immune phenotype and prognosis of the non-functional appendix neuroendocrine tumor.Methods The clinical pathological data of 13 cases with no functional neuroendocrine tumor of the appendix were retrospectively analyzed, then the changes of tumor was observed, and immunohistochemistry were done. Results No functional appendix neuroendocrine tumors could be divided into four clinical pathologic stage, which pathological features, biological behavior and prognosis were different. Incidence of non-functional appendix neuroendocrine tumor G1 were 8 cases, G2 were 3 cases, G3 or neuroendocrine carcinoma were 2 cases, immunohistochemical examination showed that, AE1 / AE3 positive were 3 cases, the Syn positive were 11 cases, CgA positive were 10 cases. 5 survival rates in three level during follow-up period were 100%, 100%, 51% respectively.ConclusionNon-functional appendix neuroendocrine tumor pathological grading and clinical staging is closely related to the prognosis, and has guidance for treatment, reasonable application of immunohistochemical can improve the diagnosis rate of neuroendocrine tumor, reduce the clinical misdiagnosis, and avoid excessive treatment.
出处
《中国医药科学》
2014年第13期120-123,共4页
China Medicine And Pharmacy
关键词
阑尾肿瘤
神经内分泌肿瘤
临床病理分析
Appendix tumor
Neuroendocrine tumor
Clinical pathological analysis
