摘要
目的:探讨双丹胶囊治疗中重度偏头痛的临床疗效及其作用机制。方法:选择76例明确诊断的中重度偏头痛患者,随机分为治疗组和对照组,各38例,对照组患者服用盐酸氟桂利嗪胶囊,治疗组患者在对照组治疗基础上服用双丹胶囊,观察治疗前后临床症状、脑血流速度、血浆ET-1的变化情况。结果:总有效率治疗组为92.1%,对照组为73.7%,治疗组优于对照组(P<0.05)。与对照组比较,治疗组患者每月发作次数、每次发作持续时间、VAS评分、脑血管血流速度、血浆ET-1均显著降低(P<0.05)。结论:双丹胶囊能改善中重度偏头痛患者脑血管血流异常,降低偏头痛发作频率、每次发作持续时间和VAS评分,提高临床疗效,其作用机制可能与降低血浆ET相关。
Objective： To investigate the clinical effect of shuangdan capsule on severe migraine as well as the mechanism. Methods： The 76 patients with diagnosed severe migraine were randomly divided into treatment and control groups, 38 cases in each. Patients received flunarizine hydrochloride capsules in the control group, and basis treatment as the control group as well as shuangdan capsule in the treatment group. Then changes of clinical symptoms, cerebral blood flow velocity, and the plasma levels of ET-1 were observed before and after treatment. Results： The total effective ratio was 92.1% in treatment group and 73.7 in control group, and the treatment group showed better efficacy than the control group （P〈0.05）. Comparing with the control group, the monthly attack frequency, duration of each episode, VAS score, cerebral blood flow velocity and ET-I were signifi- cantly decreased in the treatment group （P〈0.05）. Conclusion Shuangdan capsule can improve cerebral hemodynamic abnormalities in patients with severe migranine, reduce migraine frequency, duration of each episode and VAS score and improve the clinical efficacy, the mechanism of which may be related to the decrease of ET.
出处
《中医药导报》
2014年第8期42-45,共4页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
