摘要
目的探讨阿托伐他汀钙对脑梗死并发颈动脉粥样硬化斑块及血清C反应蛋白(CRP)的影响。方法将我院2012-01—2013-01收治的86例脑梗死患者按照入院先后顺序随机分为2组,每组各43例,其中对照组给予肠溶阿司匹林治疗,观察组在对照组基础上加用阿托伐他汀钙,比较2组治疗前后颈动脉内-中膜(IMT)厚度和斑块面积及CRP水平变化。结果观察组治疗后颈动脉IMT和斑块面积分别为(1.22±0.20)mm和(17.18±2.01)mm2,均显著低于治疗前的(1.50±0.21)mm和(24.93±2.10)mm2及对照组的(1.45±0.21)mm和(24.20±2.21)mm2,差异均具有统计学意义(P<0.05);观察组治疗后CRP水平为(5.36±0.63)mg/L,均显著低于治疗前的(10.82±1.11)mg/L和对照组的(10.13±1.08)mg/L,差异均具有统计学意义(P<0.05)。结论阿托伐他汀钙治疗脑梗死并发颈动脉粥样硬化效果显著,可有效稳定动脉粥样硬化斑块及抑制炎症反应,具有较好的临床效果。
Objective To investigate the effects of atorvastatin calcium on cerebral infarction complicated with carotid ath-erosclerotic plaque and serum C-reactive protein （CRP）.Methods 86 patients with cerebral infarction in our hospital from Jan-uary 2012 to January 2013 were randomly divided into two groups according to admission order ,each of the group had 43 ca-ses.The control group was given the therapy of enteric aspirin while the study group was given atorvastatin calcium on basis of the control group ,the thickness of carotid IM T ,plaque area and CRP levels were compared before and after treatment.Results The carotid IMT and plaque area were （1.22 ± 0.20） mm and （17.18 ± 2.01） mm2 which were significantly lower than prior treatment＇s （1.50 ± 0.21） mm and （24.93 ± 2.10） mm2 ,and the control group＇s （1.45 ± 0.21） mm and （24.20 ± 2.21） mm2 , the differences were statistically significant （P〈0.05）;The CRP levels of the study group after treatment was （5.36 ± 0.63） mg/L ,which was significantly lower than the prior treatment of （10.82 ± 1.11） mg/L and the control group＇s （10.13 ± 1.08） mg/L ,the differences were statistically significant （P〈0.05）.Conclusion The effect of atorvastatin calcium on cerebral infarc-tion complicated with carotid atherosclerosis is significantly better and it can effectively stabilize atherosclerotic plaques and re-strain the inflammatory response ,is worth of spreading in clinics .
出处
《中国实用神经疾病杂志》
2014年第12期42-43,共2页
Chinese Journal of Practical Nervous Diseases
