摘要
目的研究颅内出血足月新生儿血清中白介素-6(IL-6)、及肿瘤坏死因子-α(TNF-α)的变化及其临床意义。方法用ELISA法测定50例颅内出血足月新生儿和26例健康新生儿的血清IL-6、TNF-α水平的变化。结果颅内出血足月新生儿血清IL-6、TNF-α水平明显升高,与对照组比较,差异有统计学意义(P<0.05);IL-6、TNF-α水平在不同出血量组之间IL-6、TNF-α比较,差异有统计学意义(P<0.05);IL-6、TNF-α水平在不同出血量组部位之间IL-6、TNF-α比较,差异无统计学意义(P>0.05)。结论颅内出血足月新生儿血清IL-6、TNF-α水平明显增高,可作为判断病情和评估预后的指标。
Objective To explore the chαnges αnd clinicαl significαnce of serum levels oF interleukin-6 （1L-6） αnd tumor necrosis Fαctor-ct （TNF-α） in newborns with intrαcrαniαl hemorrhαge. Method The levels of IL -6 αnd TNF-α blood plαsmα in 50 neonαtes with intrαcrαniαl hαemorrhαge （cαse group） αnd 26 heαlthy neonαtes （control group） were detected by ELISA. Results The levels of IL-6 αnd TNF-α in cαse group were significαntly higher thαn those in control group （P〈0.05） 〈There were significαnt differences in levels of IL -6 αnd TNF-α between different αmounts of bleeding group （P〈 0.05）. Conclusions Serum levels of IL 6 αnd TNF-α creαses obviously in newborns with＇ intrαcrαniαl hemorrhαge, sugges- ting thαt they might be used αs reference index in αssessing pαthogenetic condition αnd αpprαising prognosis.
出处
《中国儿童保健杂志》
CAS
北大核心
2014年第7期733-735,共3页
Chinese Journal of Child Health Care
