摘要
本文对33例地方性慢性氟中毒患者进行了细胞遗传学检查。结果表明:氟中毒患者外周血淋巴细胞微核率和姊妹染色单体交换频率明显高于对照组,经统计学处理,都有显著性差异(P<0.01)。说明高氟可造成不同类型的 DNA 损伤。
With peripheral blood lymphocyte culture,a study of SCE and micronuclei testwas done in 24 patients with fluorosis and same number of normal people as con-trol.The results obtained showed that in the patient group the mean value ofSCE per cell and the frequency of micronuclei were 10.24±1.67 and 1.42‰,respe-ctively,while in the control only 7.62±0.80 and 0.33‰,respectively,were foundAnd both of the two respective parameters,statistically,were in significant dif-ference.These findings suggested that excess fluorine would cause increases of SCEfrequency and micronuclear number in lymphocyte and make DNA damaged.
出处
《中国地方病学杂志》
CAS
CSCD
1991年第3期129-130,共2页
Chinese Jouranl of Endemiology
关键词
氟中毒
微小核
DSCE
Micronucleus
Sister chromatid exchange
Fluorosis
