摘要
目的 :探讨正常人群脑脊液 ( CSF) Tau蛋白含量的分布范围 ,为阿尔茨海默病 ( AD)的相关研究奠定基础。方法 :采用双抗体夹心式 ELISA技术 ,对 2 0例正常对照 ( NC)组及 2 0例非 AD神经系统疾病 ( ND)组 CSF- Tau蛋白含量进行检测及统计分析。结果 :CSF- Tau蛋白含量 NC组与ND组间比较、男女性别间比较、CSF蛋白正常组和增高组间比较差异均无显著性。以年龄因素作直线相关分析 ,NC组 r=0 .5 3( P<0 .0 5 ) ,呈正相关。结论 :正常人群 CSF- Tau蛋白含量为( 1 2 5 .88± 45 .62 ) ng· L-1,并随着年龄的增长有缓慢增高的趋势 ,但与性别及 CSF蛋白总量无关。
Objective:To get the range of normal value of Tau protein in the healthy population. Methods: By using sandwich ELISA the value of Tau protein in cerebrospinal fluid (CSF) was detected in 20 cases of normal control group and in 20 cases of non Alzheimer neurological disease group (ND). Results: There was no significant difference in the value of Tau protein between control (125 88± 45 62) ng·L -1 and ND or between men and women, or between those with elevated protein and those with normal protein in CSF. The linear correlation analysis on age showed postive correlation(control: r=0 53, P <0 05). Conclusion:The value of Tau protein in CSF in healthy population is (125 88± 45 62)ng·L -1 . It is a little increase with the increase of age, but the value is not related to the sex and the total protein in CSF.
出处
《吉林大学学报(医学版)》
CAS
CSCD
北大核心
2002年第4期386-388,共3页
Journal of Jilin University:Medicine Edition
