摘要
以 L-谷氨酸为原料 ,在碱性条件下用乙酸酐作为乙酰化试剂一步合成 N -乙酰 -L-谷氨酸的新工艺。获得最佳反应条件为 :L-谷氨酸与乙酸酐的摩尔比为 1 .0∶ 1 .3 ,酰化试剂分 3次加入 ;反应 p H值为 8～ 1 0之间 ;反应温度控制在 0～ 5°C;酸化结晶 p H值为 1 .0～ 2 .0 ;反应时间 1～ 3h。产品收率为 72 .0 %。
A new synthetic method, in which N acetylation of L glutamic acid was proceeded in alkaline solution using acetic anhydride as acetylation agent, was described. The optimum conditions for the reaction were obtained: molar ratio of L glutamic and acetic anhydride was 1.0∶1.3, the acetylation agent was added in three parts, the pH of the solution must be within 8.0～10.0 during reaction and in 1.0～2.0 during acidification and crystallization, the reaction time was 1～3 hours, the reaction temperature was controlled at 0～5 °C . The yield was 72%.
出处
《化学世界》
CAS
CSCD
北大核心
2002年第7期363-365,共3页
Chemical World
