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以TAR RNA为靶的HIV-1抑制剂的研究进展

Study of HIV-1 inhibitor targeting HIV-1 TAR RNA
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摘要 Tat, an essential human immumodeficiency virus type 1 protein interacts with the transactivation response element(TAR) and stimulates transcription from the viral long-terminal repeat(LTR). Blockage of Tat-TAR interaction halts viral transcription and hence replication. In recent years a numbe of studies have suggested various chemicals and /or genetic inhibitors targeting TAR RNA for inhibition of Tat-activated transcription. Here, we report these research works. Tat, an essential human immumodeficiency virus type 1 protein interacts with the transactivation response element(TAR) and stimulates transcription from the viral long-terminal repeat(LTR). Blockage of Tat-TAR interaction halts viral transcription and hence replication. In recent years a numbe of studies have suggested various chemicals and /or genetic inhibitors targeting TAR RNA for inhibition of Tat-activated transcription. Here, we report these research works.
作者 林伟 杨铭
机构地区 北京大学天然药物及仿生药物国家重点实验室
出处 《北京大学学报（医学版）》 CAS CSCD 北大核心 2002年第4期384-388,共5页 Journal of Peking University:Health Sciences
基金 国家自然科学基金 ( 39870 183) 北京市自然科学基金 北京大学"985"基金 北京大学生命科学跨学科基金资助~~
关键词 TAR RNA HIV-1抑制剂 研究进展 靶向治疗 艾滋病 HIV-1 TAR RNA Virus inhibitors Gene expression
分类号 R978.7 [医药卫生—药品] R512.91 [医药卫生—内科学]
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参考文献10

  • 1Tamilarasu N,Huq I,Rana TM.Design, synthesis, and biological activity of a cyclic peptide: an inhibitor of HIV-1 tat-TAR interaction in human cells[].Bioorganic and Medicinal Chemistry.2000
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北京大学学报（医学版）
2002年 第4期

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