摘要
探讨了静注白三烯C_4(0.1ng·100g^(-1))对胃粘膜微循环的影响及其在急性胃粘膜损伤中的作用。实验由Wistar系雄性大鼠,实验前禁食24hr,饮水不限。发现:1.胃粘膜表层毛细血管口径迅速变细,部分消失,集合细静脉口径亦变细;10分钟时集合细静脉明显淤血和出血。2.氢气清除法证明,胃粘膜血流量明显减少,注后第15分钟时由注前1.230±0.093(M±SE)降至0.521±0.079ml·min^(-1)·100g^(-1)(P<0.01)。3.反射光谱法证明,胃粘膜局部表层微循环血液量(△Er)和Hb氧饱和度(F),均有不同程度下降。4.静注白三烯C_4(0.1ng·100g^(-1))及盐酸灌胃(0.2N1ml)均未见明显胃粘膜损伤,两者并用则损伤明显加重。结果表明,外源性白三烯C_4可引起严重胃粘膜微循环障碍,是诱发溃疡形成的重要因素之一。
The author explored the influence of exogenous LTC_4 (0.1 ng. 100g^(-1),iv) on the microcirculation of gastric mucosa and its effect on acute gestric mucosal injury. Male Wistar rats underwent a fast of 24 hours before the experiment and could drink water freely during this period. The results showed: 1. The caliber of the gastric mucosal superficial capillaries thinned and part of the capillaries disappeared. The caliber of collecting venule thinned also. After 10 minutes there were remarkable venous stasis and heamorrhage. 2. It was confirmed by the method of hydrogen clearence that the gastric mucosal flow reduced significantly. After 15 minutes of the injection, it decreased from original 1.230±0.093 to 0.521±0.079 ((?)+SE) ml, min^(-1). 100g^(-1) (P<0.01). 3. By the method of reflective spectrophotometry it was proved that both the blood volume (_△Er) in local superficial microcirculation of gastric mucosa and the oxygen saturation of Hb decreased in different degrees. 4. Injecting LTC_4 or perfusing HCl (0.2N, 1 ml) alone to the stomach had no significant gastric mucosal injury, but remarkable injury was seen when both LTC, and HCl were given together. The results indicated that exogenous LTC, could cause severe disturbance of gastric mucosal microcirculation, which was one of the main factors that could induce the ulcer formation.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1991年第6期653-655,共3页
Chinese Journal of Pathophysiology
