摘要
胎儿脑组织中存在着一类抑制小鼠白血病细胞生长的低分子量物质。这种低分子量抑制物在体外培养条件下可较强烈地抑制小鼠L801白血病细胞的生长,而对正常小鼠骨髓CFU-GM和CFU-S的毒性较小。LACA小鼠接种L801粒系白血病细胞后10-17天内全部死于白血病;然而,腹腔连续注射10天人胎脑上清液(6—8 mg/g体重),可使50%以上接种白血病细胞的小鼠免死于白血病。对存活100天以上的小鼠活杀后作病检,未见有白血病病变。
In human fetal brain tissues there is a kind of low molecular weight suppressor which can preferentially suppress routine myeloid leukemic cell (L801) growth, but with less harmful effects on the growth of normal bone marrow hemopoietic stem cells (CFU-S) and granuloid-macrophage progenitors (CFU-GM) under the condition of in vitro liquid culture system.After inoculation of L801 cells, mice died within 10-17 days due to the occurrence and development of leukemia. More than 50% of leukemia mice survived after consecutive injections of low molecular weight suppressor (6-8 mg/g body weight) isolated from human fetal brain tissues. No pathological change were observed in the mice which survived longer than 100 days after inoculation of L801 cells.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1991年第5期525-528,共4页
Chinese Journal of Pathophysiology
基金
国家自然科学基金
