摘要
采用放射免疫分析及放射配基受体分析,观察实验性NIDDM大鼠血清胰岛素、红细胞中cAMP以及红细胞胰岛素受体最大结合力。结果表明链脲霉素与高热量饲料诱发的NIDDM大鼠有明显的胰岛素抗性,即在高胰岛素水平(25.29±8.34μU/ml,P<0.001)的同时伴有明显的糖耐量减低(P<0.001)及高脂血症(血清甘油三脂2.15±0.66mmol/L,P<0.001;血清胆固醇2.82±0.44mmol/L,P<0.001)。实验还进一步表明这种胰岛素抗性与红细胞胰岛素受体最大结合力的降低(693.51±149.55cpm/10~5红细胞,P<0.001)一致。据此推测胰岛素受体结合力的降低可能是NIDDM胰岛素抗性的主要原因。
Using the radioimmunoassay and radioreceptor assay, the serum insulin and the cAPM and the maximum binding of insulin receptor in red blood cells are investigated in experimental rats. These results showed there is insulin resistance in NIDDM rats induced by streptozotocin and high caloric chow. The NIDDM rats have high levels of serum insulin (25.29±8.34μU/ml, P<0.001), accompanied with markedly impaired glucose tolerance (P<0.001 ) and hyperlipideamia (serum triglyceride 2.15±0.66mmol/L, P<0.001; serum cholesterol 2.82±0.44mmol/L, P<0.001). The work also suggested that the insutin resistance was related with decreased maximum binding of insulin receptor in red blood cells (693.51±149.55 cpm/10~5 cells, P<0.001). It is speculated that the decrease of insulin receptor may be the major cause of insulin resistance in NIDDM.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1991年第4期422-425,共4页
Chinese Journal of Pathophysiology
关键词
糖尿病
胰岛素抗性
NIDDM
Diabetes mellitus, non-insulin-dependent
Insulin resistance
Rats
