摘要
本工作对比观察了几种花生四烯酸代谢过程的酶抑制剂对Hilltop大鼠和Wistar大鼠急性缺氧性肺血管收缩反应(HPV)的影响。结果表明,Hilltop大鼠的HPV显著强于Wistar大鼠,股静脉注入U-60257B(5-脂加氧酶抑制剂,10mg/kg)抑制LTs合成,使Hilltop大鼠的HPV降低46.7%,使Wistar大鼠的HPV降低88.7%;TXA_2合成酶抑制剂U-63557A(5mg/kg)可显著减弱Hilltop大鼠的HPV,对Wistar大鼠无明显影响,从而消除了两种大鼠间的HPV差异;消炎痛(环加氧酶抑制剂)可升高Wistar大鼠的HPV,降低Hilltop大鼠的HPV。本工作提示前列腺素类物质在两种大鼠的HPV中作用不同,可能是Hilltop大鼠的HPV比Wistar大鼠强的重要原因。
The present study compared the effects of several inhibitors of arachidonic acid metabolism on hypoxic pulmonary vasoconstriction (HPV) in Hilltop and Wistar rats. The results showed that HPV is much higher in Hilltop rats than in Wistar rats. U-60257B, an inhibitor of leukotrienes synthesis, resulted in a 46.7% reduction of HPV in Hilltop rats and 88.7% in Wistar rats. After an injection of U-63557A, an inhibitor of TXA_2 synthetase, HPV was reduced in Hilltop rats and was not changed in Wistar rats, so that the difference of HPV between these two strains of rats was eliminated. Indomethacin, inhibiting the synthesis of both PGI_2 and TXA_2, markedly enhanced the HPV in Wistar rats and diminished the HPV in Hilltop rats. It is suggested that roles of different prostaglandins may be the important factor in relation to the difference of HPV between Hilltop and Wistar rats.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1991年第3期251-255,共5页
Chinese Journal of Pathophysiology
基金
国家自然科学基金
关键词
缺氧症
肺循环
白细胞三烯
Anoxia
Pulmonary circulation
Leukotrienes B
Prostaglandins
