摘要
目的 研究 2型糖尿病家系一级亲属糖耐量正常同胞与无糖尿病家族史的糖耐量正常者腰、股围及比值变化的特点和意义。方法 将 40 6个 2型糖尿病家系分出一级亲属同胞正常糖耐量 (NGT)组 ,并以同胞配偶中无糖尿病家族史的正常糖耐量者为对照组 ,再各按性别、年龄分成 2个亚组和 6个年龄亚组。比较各亚组及不同年龄亚组腰、股围及其比值的差异。结果 在 2个亚组中NGT组股围均小于对照组 (男性P <0 .0 5 ,女性P <0 .0 0 1) ;对照组和NGT组男性、女性高年龄亚组腰围、腰股比分别大于低年龄亚组 ,差异有显著性 (P均 <0 .0 5 ) ;各年龄亚组中NGT组腰股比均大于对照组 (P =0 .0 0 0 1)。
Objective To appraise the variations and significance of waist and thigh circumferences and their ratios between siblings of first degree relatives of type 2 diabetes mellitus (DM) families with normal glucose tolerance and members of non-DM families. Methods Two groups formed were: (1) Normal glucose tolerance (NGT) group from siblings of first degree relatives of 406 families of type 2 diabetes and (2) control group with normal glucose tolerance from their spouses of non-DM families. The two groups were divided into male and female subgroups. Each male or female subgroup was further divided into six age sub-groups. The variations of waist/thigh circumferences and their ratios from the above different subgroups were evaluated. Results Thigh circumferences of NGT group were smaller than that of control group in two sub-groups . Significant deviations occurred in both waist circumferences and WTR of older age sub-groups bigger than younger age sub-groups in male and female subgroups from both NGT and control groups. The waist/thigh ratios in different age sub-groups of NGT group were greater than that in different age sub-groups of control group. All P values were 0.0001.Conclusion Individuals with normal glucose tolerance in siblings of first degree relatives of type 2 DM were different from those having normal glucose tolerance as a general. One can see the tendency of abnormalities of other metabolic changes before the appearance of glucose metabolic abnormalities.
出处
《上海医学》
CAS
CSCD
北大核心
2002年第7期393-395,共3页
Shanghai Medical Journal
基金
国家自然科学基金重点项目 ( 396 30 15 0 )
上海市医学领先专业重点学科建设基金 ( 96 111 0 0 4及 9930 2 4)
关键词
2型糖尿病
家系
糖耐量
腰股围比例
NGT
Type 2 diabetes
Family
Glucose tolerance
Waist/thigh circumference and ratios
