摘要
为探讨经肝动脉化疗栓塞 (TACE)后 c- m yc蛋白在肝癌细胞凋亡中的作用 ,应用免疫组织化学方法检测 30例未经肝动脉化疗栓塞和 30例经 TACE治疗的肝癌组织中 c- m yc蛋白表达 ,采用原位末端标记法 (ISEL)检测肝癌细胞凋亡。结果显示 :两组肝癌组织中 c- myc蛋白表达率分别为 16 .6 7%和 83.33% ;肝癌细胞凋亡指数分别为 0 .0 0 88和0 .190 1。提示 :经 TACE治疗后 ,肝癌细胞凋亡率增高 ,肝癌组织中 c- m
In order to investigate the effect of c myc on hepatic apoptosis in hepatocellular carcinoma (HCC) after transcather arterial chemoembolization (TACE), expression of c myc in HCC tissues was detected by immunohistochemical method and apoptosis by ISEL method in the 60 specimens which were surgically obtained from 30 patients who had been treated by TACE (TACE group) and 30 patients without any treatments (no TACE group). Expression rate of c myc in HCC tissues of TACE group and no TACE group was 16 67 % and 83 33 % respectively. Apoptosis indexes in HCC tissues of TACE group and no TACE group were 0 0088 and 0 1901 respectively. The results indicated that after arterial chemoembolization, the apoptosis rate in HCC was raised, the expression rate of c myc in HCC tissues was significantly increased. c myc might play an important role in enhancing hepatic apoptosis in HCC.
出处
《华中科技大学学报（医学版）》
CAS
CSCD
北大核心
2002年第4期385-386,共2页
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
