摘要
本文报告了采用超选择性导管技术,以尿激酶局部动脉内灌注治疗 1例左侧大脑中动脉闭塞患者,重复脑血管造影证实闭塞的动脉开通,临床上获得明显改善。并探讨了给药途径、超选择性溶栓治疗适应症的选择、局部动脉内灌注尿激酶的方法及用量等,并且分析了国外几组资料出血性并发症的出血部位,溶栓后的再通情况及其临床症状的改善情况。
The efficacy of intravenous urokinase inthrombolytic therapy for acute stroke has not beenproven.Recently,limited clinical experience with intra-arterial injection of thrombolytic agents early afteracute stroke has been promising.We treated a patientwith acute occlusion of left proximal middle cerebralartery(MCA)by thrombolytic therapy with urokinase,using the technique of superselective intracranialcatheterization.The drug was administered via an arterialmicrocatheter that its tip had been positioned near theorigin of the occluded MCA.The total dosage ofurokinase was 250,000 units and infused over 2 hours.The second angiography demonstrated successfulrecanalization of the occluded MCA.A computerizedtomographic(CT)scan showed no detectable intracranialbleeding.Significant clininal improvement had beenobtained early after local intra-arterial infusion ofurokinase.We also reviewed some reports by otherauthors.We think that careful patient selection mightmake thrombolytic therapy safe and effective in thetreatment of acute ischemic stroke and the technique ofsuperselective intracranial catheterization holds great promise and tremendous potential for strok patients.
出处
《中风与神经疾病杂志》
CAS
CSCD
北大核心
1991年第3期145-147,共3页
Journal of Apoplexy and Nervous Diseases
