摘要
2,5-二氰基吡啶与苯乙酸和过硫酸盐,在酸性介质中银盐催化下,经自由基型亲核取代反应引入苄基,生成2,5-二氰基-4-苄基吡啶(Ⅲ)。Ⅲ以多聚磷酸为缩合剂,发生分子内环化反应,生成了文题化合物(Ⅳ)。Ⅲ和Ⅳ的结构以质谱、核磁共振谱、红外光谱等手段予以确定。
The title compound(Ⅳ)has been synthesized in acidic medium through benzylation of 2,5-dicyano-pyridine by homolytic nucleophilic aromatic substitution, followed by intramolecular cyclization of the intermediate(Ⅲ) (a pyridine derivative containing a benzyl group in ortho-position to the cyano group), in the presence of polyphosphoric acid. The structures of Ⅲ and Ⅳ have been identified by MS, NMR, and IR, respectively.
关键词
苯并异喹啉
合成
synthesis
isoquinoline
nucleophilic reaction
benzo [g] isoquinoline
2
5-dicyanopyridine
polyphosphoric acid
