摘要
从临沧地不容(Stephanta lincangensis H.S.Lo.et M.Yang)的块根中分得8种生物碱,根据其理化性质、波谱分析及化学方法,证实其中6种为已知生物碱,即左旋四氢巴马汀(Ⅰ),卡巴任(Ⅱ).异紫堇定碱(Ⅲ),紫堇定碱(Ⅳ).罗默碱(Ⅴ),巴马汀碱(Ⅵ)。化合物(Ⅶ),经测定其结构为4-羟基-2,3,9,10-四甲氧基原小檗碱,命名为临沧碱(Liacangenine),化合物(Ⅷ)其结构测定为左旋1,2,3,9,10-五甲氧基四氢原小檗碱,两者均为新化合物。
Eight alkaloids have been isolated from the roots of Stephania lincangensis H. S. Lo. et M. Yang which is a novel species growing in Lincang district of Yunnan province. The structures of these compounds were identified as I-tetrahydropalmatine (Ⅰ), capaurine (Ⅱ)isocorydine (Ⅲ), corydine (Ⅳ), roemerine (Ⅴ) and palmatine (Ⅵ) by means of spectral and chemical methods. Two others, namely lincangenine [4-hydroxy-2,3,9,10-pentamethoxyprotoberberine (Ⅶ)] and 1-1,2,3,9,10-pentamethoxytetrahydroprotoberberine (Ⅷ), are new alkaloids, I-tetrahydropalmatine is the main alkaloid with 2.39% yield.
基金
国家自然科学基金资助项目
关键词
临沧地不容
临沧碱
生物碱
Stephania lincangensis
Alkaloids
Lincangenine
1-1,2,3,9,10-pentamethoxytetrahydroprotoberberine
