摘要
目的 :探讨海洛因依赖者在戒毒前后肝、肾功能的变化。方法 :收集武汉市戒毒中心 60例住院患者戒毒前后的丙氨酸氨基转移酶 (ALT)、天冬氨酸氨基转移酶 (AST)、血尿素氮 (BUN)、血肌酐 (Cr)及尿液α1 MG、清蛋白 (ALB)的检测结果 ,将之与湖北省新华医院 70例健康体检者的肝、肾功能检测结果相比较。结果 :海洛因依赖者戒毒前血清ALT、AST、尿液α1 MG、ALB含量均显著高于对照组 ,而血清BUN、Cr则变化不明显 ;戒毒后 ,血清ALT、AST较戒毒前有所降低 ,但仍明显高于对照组 ,尿液α1 MG、ALB则趋于正常。结论 :海洛因依赖者存在肝肾功能损害 ,其中肾功能损害较轻 ,宜用早期诊断指标如尿液α1 MG、ALB监测 ;肝功能损害有一定的持续性 ,不能完全随戒毒治疗而恢复。提示在进行戒毒治疗的同时 ,要密切监测肝、肾功能 ,并了解其变化规律 。
Objective:To study the changes in liver and kidney functions of heroin dependents before and after abstinence. Method:The values of serum alanine aminotransferase (ALT), aspartate transominase (AST), creatinine (Cr), whole blood nitrogen (BUN), urine alpha microglobulin (αl MG) and albumin (ALB) obtained before and after abstinence from 60 heroin dependence hospitalized in the Abstinence Center of Wuhan were compared with those from 70 normal people coming to the Xinhua hospital for somatoscopy. Results:The values of serum ALT, AST, urine αl MG and ALB obtained from heroin dependence before abstinence were obviously higher than those of the normal controls, while the changes in BUN and serum Cr of the dependence were insignificant. After abstinence, the serum ALT and AST decreased to some extent as compared with the pre abstinence values, but were still evidently higher than those of the normal controls. However their urine αl MG and ALB tended to turn normal. Disturbances of liver and kidney functions were demonstrated in heroin dependence. The disturbances of kidney functions were less serious and could be monitored early by examining the presence of urine αl MG and ALB. The disturbances of liver functions, however, were found to persist for a certain period. Normal liver functions were not completely restored with the termination of abstinence. Conclusion:It is important to monitor changes in liver and kidney functions of heroin dependence during abstinence and to understand the laws of these changes so as to plan for a better combined treatment.
出处
《医药导报》
CAS
2002年第8期501-503,共3页
Herald of Medicine
关键词
海洛因依赖者
戒毒
肾功能
肝功能
Heroin
Dependence
Abstinence
Functions of the liver
Functions of the kidney
