摘要
目的 探讨中老年妇女骨质疏松发病危险因素。方法 检测 1 4 7例中老年妇女血清睾酮 (T)、雌二醇 (E2 )、降钙素 (CT)、骨钙素(BGP)、甲状旁腺激素 (PTH)、三碘甲状腺原氨酸 (T3)、甲状腺激素 (T4 ) ,并用双能 X线骨密度仪测定腰椎、髋部、前臂骨密度。根据测定结果 ,分出骨质疏松组和非骨质疏松组。记录两组对象的年龄、身高、体重、体重指数、初潮年龄、绝经年龄、初孕年龄、初产年龄、妊娠次数、产次 ,并对数据进行统计学分析。结果 中老年女性骨质疏松的发生率为 54.42 %。非骨质疏松组与骨质疏松组比较 ,两组的年龄、身高、体重、体重指数、孕次、产次、血清 E2 、T4 均有显著性差异 (P<0 .0 0 1～ 0 .0 5)。多因素分析显示 ,年龄、体重、产次、血清 E2 水平与 L3骨密度相关 (P<0 .0 0 1～ 0 .0 5)。结论 骨质疏松受多种因素的影响 ,年轻时控制产次 ,可能减少中老年后骨质疏松的发生。中老年妇女维持适当的体重、适当补充雌激素有可能对骨量丢失有保护作用 。
Objectives To explore the risk factors of osteoporosis in middle aged and aged women. Methods 147 females were included in the study. Their blood T, E2, BGP, CT, PHT, T3 and T4 were measured. Their bone mineral density were also measured at lumbar spine, hip and radius using dural energy X ray absorptiometry scanner. They were divided into osteoporosis and non osteoporosis groups according to the measured results. Height, weight and body mass index were determined and a clinical questionnaire was administered to assess the risk factors which related to bone mineral density, such as age, age at menarche and natural menopause, age at first pregnancy and parturition, times of pregnancy and parturition. Results The incidence of osteoporosis was 54.42%. There was significantly difference between the two groups in age, height, weight, body mass index, times of pregnancy and parturition ( P <0.001～<0.05). Conclusions Multiple factors may give rise to osteoporosis in women. If women reduce the times of parturition in young, they might reduce the incidence of osteoporosis after middle aged. Maintaining suitable body weight in middle aged and aged women and taking hormone replacement therapy after menopause could prevent their bone mass from loss, and it may reduce the potential risk factors of osteoporosis.
出处
《中国老年学杂志》
CAS
CSCD
北大核心
2002年第4期249-250,共2页
Chinese Journal of Gerontology
基金
广西壮族自治区科技厅科研基金资助项目 (桂科回 992 0 0 1 9)
