摘要
脑室和中脑导水管周围灰质(PAG)内注射 P 物质(SP),观察大鼠下丘脑、海马和纹状体内5-羟色胺(5-HT)含量的变化及其与痛阈、电针镇痛的关系,结果如下:(1)脑室注射 SP可使痛阈和下丘脑、海马内5-HT 含量显著升高;应用对氯苯丙氨酸降低脑内5-HT 后。
The purpose of this study is to observe the effect of intracerebroventricular (iv)and intra-PAG injection of substance P (SP)on serotonin(5-HT)conte- nts of hypothalamus,hippocampus,striatum and its relation with the change of pain thre shold,electroacupuncture (EA)analgesia,The results were as follows:(1)After icy injection of SP,the pain threshold and the 5-HT co- ntents of hypothalamus,nippocampus were significantly increased,After de- pletion of the 5-HT contents in brain by pCPA,the inhibitor of 5-HT synthe- sis,the effect of SP on elevating pain threshold and the 5-HT contents of hypothalamus,hippocampus were markedly attenuated,bud did not prevent the analgesic effect of SP (2)The pain threshold and the 5-HT contents of hypo- thalamus,hippocampus were dose-dependently increased by intra-PAG injection of SP.(3)The intra-PAG injection of SP introduced simultanously with high or low frepuency EA did not affect the change of 5-HT contents of three brain regions,but caused a more marked elevation of pain threshold,These results suggest that the serotoninergic system may be activated by PAG for the medi- ation of SP induced analgesia.There is a synergic action of analgesia bet- ween the effects produced by intra-PAG injection of SP and those by high or low frepuency EA.
出处
《针刺研究》
CAS
CSCD
1991年第2期125-128,共4页
Acupuncture Research
