摘要
目的 研究短程连续使用胸腺素α1对肝动脉插管化疗栓塞 (TACE)治疗原发性肝癌辅助治疗作用。方法 选择确诊为原发性肝癌 ,愿意接受在TACE同时使用胸腺素α1的病人 32例 ,男2 7例 ,女 5例。Child分分A级 9例 ,B级 2 0例 ,C级 3例。年龄 34～ 6 8岁 ,平均 5 2 33± 9 6 4岁。在TACE当天开始皮下注射胸腺素α1,1 6mg/次 ,每天 1次 ,10d为一疗程。 结果 肝区疼痛缓解率为 6 3 16 % (12 / 19) ;食欲增加为 6 6 6 7% (18/ 2 7) ;乏力改善为 6 5 6 3% (2 1/ 32 )。AFP逐渐降低 ,由治疗前的 5 12 34± 32 0 75ng/ml降到治疗后 30d的 2 15 12± 4 9 2 2ng/ml(P <0 0 1)。而ALT在TACE后明显升高 ,治疗后 30d恢复到治疗前水平。其他肝功能指标和血白细胞无明显变化。治疗后 30dCD3、CD4由治疗前的 5 3 38± 8 31和 37 5 5± 7 4 7增加到 6 5 74± 8 6 3(P <0 0 5 )和 4 5 34± 9 81;CD8由 34 86± 5 38降到 2 9 2 6± 4 4 9;CD4 /CD8比值和NK细胞活性由 1 0 7± 0 5 6和4 2 38± 10 15增加到 1 5 5± 0 77和 5 1 91± 9 35。无胸腺素相关的并发症。结论 胸腺素α1可提高TACE后原发性肝癌病人的免疫功能 ,是一种安全。
Objective To investigate the effect of thymosin alpha 1 on hepatocellular carcinoma (HCC) after transcatheter arterial chemotherapy and embolization (TACE). Methods Thirty two patients (27 males and 5 females) with HCC were treated by TACE and thymosin alpha 1. Thymosin alpha 1 (1 6 mg) was used on the first day of TACE for consecutive 10 days. Results (1) Amongst these patients, relief of pain in the hepatic region was achieved in 63 16% (12/19), appetite improvement in 66 67% (18/27) and fatigue relief in 65 63% (21/32). (2) After the treatment, AFP level was gradually decreased from 512 34±320 75 ng/ml to 215 12±49 22 ng/ml (P<0 01). After TACE, ALT level was increased a little and then gradually returned to normal before the treatment. (3) In 30 days after the treatment, the levels of CD3, CD4, CD4/CD8 and NK cell activity were increased from 53 28±8 31, 37 55±7 47, 1 07±0 56 and 42 38±10 15 to 65 74±8 63, 45 34±9 81, 1 55±0 77 and 51 91±9 35, respectively. The level of CD8 was decreased from 34 86±5 38 to 29 26±4 49. No complication related to thymosin alpha 1 was found. Conclusions Thymosin alpha 1 can improve the immune function of patients with HCC after TACE.
出处
《中华肝胆外科杂志》
CAS
CSCD
2002年第7期417-419,共3页
Chinese Journal of Hepatobiliary Surgery
关键词
肝动脉插管化疗栓塞
胸腺素Α1
治疗
原发性肝癌
Carcinoma, hepatocelluar
Thymosin alpha 1
Transcatheter arterial chemotherapy and embolization
