摘要
目的 :探索碳酸氢钠等化合物对小鼠河豚毒素急性中毒的拮抗作用。方法 :用小鼠死亡时间评价碳酸氢钠等 5种化合物拮抗河豚毒素效果。结果 :碳酸氢钠和氢溴酸东莨菪碱对河豚毒素有明显的拮抗作用 ,可使小鼠 10 0 %或 80 %存活 (P <0 .0 1)。碳酸氢钠拮抗效果比氢溴酸东莨菪碱明显。阿托品和半胱氨酸没有明显效果。结论
Objective: To explore the antagonistic effects of some compounds to TTX poisoning in mice. Methods: The death time of mice was determined, after ip injection with TTX and some other compounds. Results: NaHCO 3 and scopolamine hydrobromide showed markedly antagonistic effect to TTX poisoning in mice, and saved the lives of mice by 80% to 100%(P<0.01). The antagonistic effect of NaHCO 3 to TTX poisoning was better than that of scopolamine hydrobromide. However atropine and L-cysteine did not show sighificant effect in the treatment of TTX poisoning. Conclusions: NaHCO 3 and scopolamine hydrobromide can be used to treat TTX poisoning.
出处
《山东大学学报（医学版）》
CAS
2002年第3期227-229,共3页
Journal of Shandong University:Health Sciences
基金
山东省卫生厅资助课题 ( 9810 10 113)
