摘要
目的 研究在新斯的明拮抗维库溴铵肌松作用的过程中不同浓度的异氟醚对老年病人肌松恢复的影响。方法 老年组和对照组各 30例 ,每组又随机分为 3个亚组 ,分别为 :E1、E2 、E3和A1、A2 、A3 。T1恢复到 2 5 %时静注新斯的明 0 0 4mg/kg。各小组在拮抗时停止吸入异氟醚的时间不同 ,观察 16分钟内T4 /T1的恢复情况。结果 E1比A1、E2 比A2 、E3 比A3 、A2 比A3 、A1比A3 、E1比E3 ,16分钟时的T4 /T1值均有统计学差异。老年组与对照组比较恢复程度减低。拮抗后吸入异氟醚时间长的组 ,肌松恢复程度减低。结论 异氟醚对新斯的明拮抗维库溴铵肌松作用的过程有抑制作用 。
Objective To study the influences of different concentrations of isoflurane on the reversal of neuromuscular blockade in the elderly during antagonization of vecuronium-induced neuromuscular block with neostigmine.Methods Sixty patients were equally divided into elderly group (group E) and control group (group A).Each group was subdivided into three subgroups.When T 1 had recovered spontaneously to 25% of the control,all patients received neostigmine 0.04mg/kg.The duration of isoflurane inhalation was different in each subgroup after neostigmine was given.TOF ratios were recorded continuously over the next 16min.Results There were significant differences of TOF ratios at the end of 16min between groups E 1 and A 1,E 2 and A 2,E 3 and A 3,A 2 and A 3,A1 and A 3,and E 1 and E 3.The degrees of recovery in the elderly groups were slower than those in the control groups.The longer isoflurane inhalation after neostigmine injection the lower degree of the recovery of neuromuscular blockade.Conclusion Isoflurane has a depressive effect on the reversal of vecuronium-induced neuromuscular blockade after antagonization with neostigmine,especially in the elderly.
出处
《临床麻醉学杂志》
CAS
CSCD
2002年第7期356-358,共3页
Journal of Clinical Anesthesiology
关键词
异氟醚
新斯的明
维库溴铵
老年人
肌松
Isoflurane
Neostigmine
Vecuronium
Elderly
Neuromuscular block
