摘要
目的 探讨α1 抗胰凝乳蛋白酶基因 (ACT)A/T多态性和中国人群脑出血的相关性。方法 采用病例 对照研究方法 ,用聚合酶链反应 限制性片段长度多态性的方法检测 2 2 0例脑出血和2 76例健康对照者的ACT基因多态性 ,用多元Logistic回归模型分析与脑出血的相关性。结果 经年龄、性别、饮酒、吸烟、文化程度、糖尿病、高血压调整后 ,可见 (1)ACTAT、TT基因型导致脑出血发病危险性显著增加 (OR值分别为 2 33,2 17,P <0 0 5 ) ,但与高血压无相关性。 (2 )高血压导致脑出血发病危险性显著增加 (OR =8 17,P =0 0 0 0 )。 (3)ACTAT/TT和高血压对脑出血的发生有明显交互作用 ,显著增加脑出血的危险性 ,交互作用系数为 2 84 ,OR值为 15 92 ,为 4型交互作用中的超相乘模型。ACTAT/TT和糖尿病对脑出血的发生为 3型交互作用中的相加模型 ,OR值为 2 89。结论 ACT基因A/T多态性和高血压是脑出血发病的独立危险因素。AT/TT基因型和高血压及糖尿病对脑出血均有交互作用。
Objective To explore the association between alpha 1 antichymotrypsin (ACT) gene A/T polymorphism and cerebral hemorrhage among Chinese people Methods The DNA of peripheral leucocytes was extracted from 220 patients with cerebral hemoprrhage and 276 controls PCR RELP was used to determine the ACT gene polymorphism Multiple Logistic regression was performed to explore the risk factors for cerebral hemorrhage Results After adjusting age, gender, alcohol drinking, smoking, education ,history of diabetes mellitus and primary hypertension, the analysis showed: (1) the ACT AT and TT genotypes increased the risk of cerebral hemorrhage( OR =2 33 and 2 17 respectively, P <0 05 ), but were not associated with primary hypertension Such association was more prevalent in hypertensive cerebral hemorrhage (2)Primary hypertension significanlly increased the risk of cerebral hemorrhage ( OR =8 17, P =0 000) (3) A significant gene environment interaction, super multiplicative type 4 interaction, was shown between both ACT AT and TT genotypes and primary hypertension with an interaction index (r) value of 2 84 and an OR value of 15 92 A significant additive type 3 gene environment interaction was shown between both ACT AT and TT genotypes and diabetes mellitus with an OR value of 2 89 Conclusion ACT gene polymorphism and primary hypertension are both independent risk factors of cerebral hemorrhage The ACT AT and TT genotypes show a significant gene environment interaction, however, of differfent types, with both primary hypertension and diabetes mellitus in the occurrence of cerebral hemorrhage
出处
《中华医学杂志》
CAS
CSCD
北大核心
2002年第13期915-917,共3页
National Medical Journal of China
