摘要
分析幽门螺杆菌的 cag A及 vac A状态对抗生素疗效的影响。对广州地区 12 6例幽门螺杆菌感染的消化性溃疡病或功能性消化不良患者应用含克拉霉素的三联方案进行一周治疗 ,在治疗前收集胃窦活检标本进行幽门螺杆菌培养 ,并用 PCR检测 cag A及 vac A状态。在治疗结束 4周后进行 1 3C呼气试验检测。结果消化性溃疡病与 cag A阳性幽门螺杆菌感染密切相关 ,cag A及 vac A状态对含克拉霉素的三联一周抗幽门螺杆菌治疗效果均无明显的影响。提示幽门螺杆菌的 cag A状态与消化性溃疡病密切相关 ,但是 cag A及 vac A状态对抗生素疗效无明显影响。
To determine the effect of the cagA and the vacA status on the efficacy of antibiotic therapy against Helicobacter pylori(H.pylori) clinical isolates. 126 patients with H.pylori infection and peptic ulcer disease or functional despepsia in Guangzhou region were treated by triple regimens containing clarithromycin for one week. H.pylori was cultured from gastric antral biopsy specimens which were taken before treatment, and the cagA and vacA status was determined by polymerase chain reaction. Eradication of H.pylori was assessed by 13 C urea breath test 4 weeks after the treatment was finished. The results showed peptic ulcer disease was strongly associated with the cagA positive H.pylory infection. The cagA and the vacA status hadn′t significantly effect on the efficacy of anti H.pylori therapy with triple regimens containing clarithromycin for one week. The investigation suggested that the cagA presence of H.pylori was strongly associcated with peptic ulcer disease, but the cagA and vacA status hadn′t significantly effect on the efficacy of antibiotic therapy.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2002年第7期427-430,共4页
Chinese Journal of Antibiotics
基金
广东省自然科学基金 (No.970 4 6)
广东省医学科学基金 (B2 0 0 0 0 2 7)资助项目
