摘要
目的 探讨丹参对自体静脉移植替代动脉后早、中期通畅率及增殖病变的影响。方法 将大鼠自体颈静脉移植于腹主动脉 ,分丹参组和对照组 ,丹参组于术前 1d开始管饲丹参注射液 [2 4g/ (kg·d ) ]直至取材 ;对照组管饲相同体积的生理盐水。于术后 1d、3d、1w、2w、4w及 8w取材 ,观测移植静脉通畅率、内 中膜厚度及细胞核增殖抗原(PCNA)的表达。结果 移植静脉通畅率两组间差异无显著性意义 (P>0 .0 5 ) ,术后 2w、4w及 8w移植静脉壁厚度丹参组较对照组减少 1/ 3 ,差异有非常显著性意义 (P<0 .0 1) ,丹参组PCNA阳性细胞数较对照组明显减少 (P<0 .0 1)。结论 丹参可抑制移植静脉增殖病变 ,对移植静脉早。
Objective To assess the effects of Radix Salviae Miltiorrhizae (RSM) on patency and proliferation lesion of autologous vein to artery grafts in the early middle stage.Methods Autologous jugular vein was grafted into abdominal artery in the rats. The rats were divided into two groups: RSM group and control group. The rats in RSM group were fed with RSM [24 g/(kg·d )],which began 1 day before operation and continued until harvesting. Vein grafts were harvested at 1,3 days, 1, 2, 4 and 8 weeks after surgery for examining the patency, thickness of intima media and expression of proliferating cell nuclear antigen (PCNA). Results No significant differences existed in patency of vein grafts between the two groups ( P >0.05). The intima media thickness of the vein grafts in RSM group decreased 1/3 compared with control group at 2, 4 and 8 weeks ( P <0.01). The PCNA positive cells in RSM group reduced significantly as compared to the control group ( P <0.01). Conclusion RSM can inhibit proliferation lesion of vein grafts but has no influence on patency of vein grafts in the early middle stage.
出处
《中国普外基础与临床杂志》
CAS
2002年第4期232-234,共3页
Chinese Journal of Bases and Clinics In General Surgery
关键词
自体静脉移植
丹参
通畅率
增殖
动脉
动物实验
Autologous vein graft Radix salviae miltiorrhizae Patence Proliferation
