摘要
目的 分析α受体阻滞剂对良性前列腺增生 (BPH)患者症状的影响。 方法 对 14 8例BPH患者进行 4周α受体阻滞剂治疗 ,记录并分析治疗前后患者症状、IPSS评分、最大尿流率、平均尿流率及剩余尿量情况。 结果 治疗 4周后 ,患者平均IPSS评分、最大尿流率、平均尿流率及剩余尿量均有显著改善。各项症状中 ,夜尿次数的改善显著低于其它症状的改善。 35例 (2 3.6 % )患者治疗后生活质量评分没有改善 (主观不满意组 ) ,IPSS改善程度明显低于生活质量评分有提高的患者(主观满意组 ) ,但两组间最大尿流率及平均尿流率的改善差别无显著性意义。
Objective To analysis the impact of α blocker therapy on symptoms of benign prostatic hyperplasia(BPH). Methods 148 cases of BPH patients had been treated with α blocker for 4 weeks. Symptom score, uroflowmetry and post voiding residual urine were recorded and analyzed. Results After 4 weeks of treatment, the IPSS, uroflowmetry and residual volume were improved significantly, P <0.001.All of the symptoms, including frequency,incomplete emptying, hesitancy, urgency, weak urinary stream, intermittence and nocturia, were improved significantly, P <0.001. However, the improvement of nocturia was significantly lower than that of the other symptoms, P < 0.05 . Among the 148 patients, 35(23.6%) complained no improvement of their quality of life.These unsatisfied cases had a lower IPSS improvement than those who had improved life quality score, P <0.001, while their improvement of uroflowmetry had statistically significant difference, P >0.1. Conclusions Reduction of symptoms and improvements of uroflowmetry in BPH patients treated with α blocker.might be initiated through different mechanisms.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
2002年第6期358-360,共3页
Chinese Journal of Urology
