摘要
目的探讨巨块型宫颈癌术前3种治疗方式的疗效及临床意义。方法 巨块型宫颈癌术前分为3种方式治疗。后装组：24例采用后装治疗，A点总量15～30Gy；化疗组：32例采用改良VBP方案行全身化疗3个疗程；综合组：34例进行宫颈肿瘤组织间插植放疗同期化疗。结果近期有效率后装组、化疗组、综合组分别为58.33％、81.25％、91.18％，综合组与后装组比较，P＜0.01差异有显著性；不良反应：胃肠道反应与白细胞降低，化疗组明显高于其他两组；直肠反应与膀胱反应，后装组高于化疗组和综合组。结论组织间插植放疗同期化疗，近期疗效好、副反应低，而且提高了患者的生活质量，是巨块型宫颈癌术前治疗的一种较好的方法。
Purpose To evaluate the therapeutic effects and clinical value of three therapies in patients with bulking carcinoma of the cervix before surgery. Methods The patients with bulking carcinoma of the cervix were randomly divided into three groups according to the therapies, received respectively before surgery: (1) The afterloading irradiation group including 24 cases received afterloading irradiation of 15 ~ 30Gy in total at the point of A. (2)The chemotherapy group of 32 cases received three courses of systemic chemotherapy with improved VBP. (3) The comprehensive group of 34 cases received a combination of interstitial plantment irradiation and simultaneous chemotherapy. Results The short-term efficacioua rates of the afterloading irradiation group, the chemotherapy group and the comprehensive group were 58.33% , 81. 25% ,91. 18% respectively. There was significant difference in efficacy between the comprehensive group and the afterloading irradiation group. The side effects such as gastrointestinal reaction and reduction of leukcocytes in the chemotherapy group were more serious than those in the other two groups while the incidence of the reaction of rectum and urinary bladder of the afterloading irradiation group was much higher than those of the chemotherapy group and comprehensive group. Conclusion Interstitial plantment irradiation plus simultaneous chemotherapy is safe and valuable in the treatment of bulking carcinoma of the cervix before surgery, it also improves the life quality of the patients.
出处
《青海医学院学报》
CAS
2002年第2期21-22,共2页
Journal of Qinghai Medical College
关键词
巨块型宫颈癌
后装治疗
VBP方案化疗
组织间插植放疗
Bulking Carcinoma of the cervix Afterloading irradiation VBP, Interstitial plantment irradiation.
