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短蛋白聚糖研究进展 被引量：1

Progress in the study of brevican
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摘要 短蛋白聚糖 (brevican)是一种中枢神经系统特有的硫酸软骨素蛋白聚糖 ,是脑内最丰富的细胞外基质分子之一。Brevican的表达仅限于中枢神经系统 ,在神经发育和脑损伤后胶质增生过程中均有明显增高。近来的研究表明 ,brevican在脑胶质瘤中有高度特异的表达并与其侵袭性相关 。
作者 韩晞 董艳 卢亦成
机构地区 第二军医大学长征医院神经外科
出处 《生理科学进展》 CAS CSCD 北大核心 2002年第3期248-250,共3页 Progress in Physiological Sciences
基金 上海市科委重点资助课题 (994 1190 89)
关键词 短蛋白聚糖 研究进展 神经发育 神经损伤 胶质瘤
分类号 Q421 [生物学—神经生物学]
  • 相关文献

参考文献10

  • 1[1]Rauch U, Meyer H, Brakebusch C, et al. Sequence and chromosomal location of the mouse brevican gene. Genomics, 1997, 44:15～21.
  • 2[2]Gray SC, Zerillo CA, Chiang VL, et al. cDNA cloning, chromosomal localization, and expression analysis of human BEHAB/brevican, a brain specific proteoglycan regulated during cortical development and in glioma. Gene, 2000, 256:139～147.
  • 3[3]Sander V, Mullegger J, Lepperdinger G. Xenopus brevican is expressed in the notochord and the brain during early embryogenesis. Mech Dev, 2001 2:251～253.
  • 4[4]Jaworski DM. Kelly GM, Hockfield S. The CNS-specific hyaluronan-binding protein BEHAB is expressed in ventricular zones coincident with gliogenesis. J Neurosci, 1995, 15:1352～1362.
  • 5[5]Ogawa T, Hagihara K, Suzuki M, et al. Brevican in the developing hippocampal fimbria: differential expression in myelinating oligodendrocytes and adult astrocytes suggests a dual role for brevican in central nervous system fiber tract development. J Comp Neurol, 2001 432:285～295.
  • 6[6]Jaworski DM, Kelly GM, Hockfield S. Intracranial injury acutely induces the expression of the secreted isoform of the CNS-specific hyaluronan-binding protein BEHAB/brevican. Exp Neurol, 1999, 157:327～337.
  • 7[7]Jaworski DM, Kelly GM, Piepmeier JM, et al. BEHAB (brain enriched Hyaluronan binding) is expressed in surgical samples of glioma and in intracranial grafts of invasive glioma cell lines. Cancer Res, 1996, 56:2293～2298.
  • 8[8]Matthews RT, Gary SC, Zerillo C, et al. Brain-enriched hyaluronan binding (BEHAB)/brevican cleavage in a glioma cell line is mediated by a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family member. J Biol Chem, 2000, 275:22695～22703.
  • 9[9]Nakamura H, Fujii Y, Inoki I, et al. Brevican is degraded by matrix metalloproteinases and aggrecanase-1 (ADAMTS4) at different sites. J Biol Chem, 2000, 275:38885～38890.
  • 10[10]Nutt CL, Zerillo CA, Kelly GM, et al. Brain enriched hyaluronan binding (BEHAB)/ brevican increases aggressiveness of CNS-1 gliomas in Lewis rats. Cancer Res, 2001, 61:7056～7059.

同被引文献12

  • 1李立新.反应性星形胶质化的形成机制及研究进展[J].国外医学（生理病理科学与临床分册）,1996,16(4):278-280. 被引量：12
  • 2Yamada H, Watanabe K, Shimonaka M, et al. Molecular cloning of brevican, a novelbrain proteoglycan of the aggrecan/versican family. J Biol Chem, 1994, 269:10119-10126.
  • 3Wu RR, Couchman JR, cDNA cloning of the basement membrane chondroitin sulfate proteoglycan core protein, Bamacan: a five domain structure including coiled - coil motifs.J Cell Biol, 1997,136:433 - 444.
  • 4Jaworski DM, Kelly GM, Hockfield S. BEHAB, a new member of the proteoglycan tandem repeat family of hyaluronan - binding proteins that is restricted to the brain. J Cell Biol, 1994, 125:495-509.
  • 5Jaworski DM, Kelly GM, Hockfield S. Intracranial injury acutely induces the expression of the secreted isoform of the CNS -specific hyaluronan - binding protein BEHAB/brevican. Exp Neurol, 1999, 157:327 - 337.
  • 6Fraser JRE, Laurent T, Cand UBG, et al.Hyaluronan : its nature, distribution, functions and turnover. J Intern Med, 1997,242:27 - 33.
  • 7Brakebusch C, Seidenbecher CI, Asztely F,et al. Brevican- deficient mice display impaired hippocampal CA1 long - term potentiation but show no obvious deficits in learning and memory. Mol Cell Biol, 2002, 22:7417- 7427.
  • 8Pekny M, Leveen P, Pekna M, et al. Mice lacking glial fibriUary acidic protein displayastrocytes devoid of intermediate filaments but develop and reproduce normally. EMBO J, 1995, 14:1590-1598.
  • 9Yang HY, Lieska N, Kriho V, et al. A subpopulation of reactive astrocytes at the immediate site of cerebral cortical injury.Exp Neurol, 1997, 146:199-205.
  • 10Amat JA, Ishiguro H, Nakamura K. et al.Phenotypic diversity and kinetics of proliferating mlcrtglla and astrocytes following cortical stab wounds. Glia, 1996, 16:368-382.

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生理科学进展
2002年 第3期

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