摘要
NAD(P)H :醌氧化还原酶 1(NQO1)是真核细胞内普遍存在的一类黄素蛋白酶 ,它专性催化胞内双电子还原反应 ,能够解除醌类物质对细胞的毒害 ,从而起到保护细胞的作用。同时 ,它又能活化一些醌类抗肿瘤药物。本文综述了NQO1的基因结构、多态性、功能和活性调节 。
NAD(P)H:Quinone oxidoreductase (NQO1) is a kind of flavoprotein that catalyzes the obligatory two electron reduction in eukaryotic cells. It can bioactivate certain antitumor quinone drugs as well as detoxify many xenobiotics and their derivatives, which lead to the protection of cells. This review focuses on NQO1 gene and protein structure, enzyme mechanism, activity regulation and its role in cellular redox cycling and tumor therapy.
出处
《生理科学进展》
CAS
CSCD
北大核心
2002年第3期225-229,共5页
Progress in Physiological Sciences
基金
国家自然科学基金 (39970 6 4 9)
浙江省自然科学基金(部分) (30 15 2 9)资助课题
