摘要
目的 观察重组人脑钠肽 (rhBNP)对麻醉犬血流动力学和肾功能的作用。方法 给麻醉开胸犬恒速输注rhBNP(采用累积给药方式 ) ,或iv米力农后 ,进行血流动力学测定 ,并测定尿量、尿钠和血钠含量。结果 rhBNP可使MAP ,LVSP ,LVdp dt,PAP ,LVEDP ,TPR及RVR呈剂量依赖性下降 ,CO有增加趋势 ,尿量和尿钠排出量呈剂量依赖性增加。米力农则明显降低MAP ,PAP ,LVEDP ,TPR ,RBF及RVR ,升高LVSP ,LVdp dt和CO ,加快心率 ,对尿量、尿钠排出量和血钠无明显影响。结论 rhBNP能明显降低心脏前后负荷 ,改善心脏功能 ;可舒张肾动脉 ,有扩张血管和利尿排钠作用。米力农则有正性肌力和频率作用 ,无利尿利钠作用。
AIM To study the effects of rhBNP and milrinone on the cardiac hemodynamics and renal function in anesthetized dogs. METHODS The actions of rhBNP given cumulatively iv 10,30 and 100 ng·kg -1 for 30 min and milrinone of single dose (100 μg·kg -1 , iv) on cardiac hemodynamics and renal function were studied in anesthetized open-chest dogs. RESULTS In anesthetized dogs (n=7) intravenous infusion of rhBNP at 10～100 ng·kg -1 , caused decreases in mean arterial pressure (MAP), left ventricular systolic pressure (LVSP), LVdp/dt max , pulmonary arterial pressure (PAP), left ventricular end diastolic pressure (LVEDP), total peripheral resistance (TPR) and renal vascular resistance (RVR) dose-dependently, without significant changes in cardiac output (CO), LV(dp/dt)/P, renal blood flow (RBF) and heart rate (HR), increases in urinary volume and sodium excretion. In anesthetized dogs (n=6), there were remarkable decreases in MAP, LVEDP, PAP, TPR, RBF, RVR and urinary volume following the MIL (100 μg·kg -1 , iv), with significant increases of LVSP, ±LVdp/dt max , HR and CO, but no marked changes in urinary volume and sodium excretion. CONCLUSION rhBNP reduces the pre-load and after-load in the anethetized dogs but showed no distinct effect on the contractility of the heart. Positive inotropic and chronotropic actions have been demonstrated after intravenous injection of milrinone 100 μg·kg -1 in anesthetized dogs.
出处
《药学学报》
CAS
CSCD
北大核心
2002年第7期506-509,共4页
Acta Pharmaceutica Sinica
