摘要
目的考察合欢皮水煎剂对戊巴比妥钠诱导小白鼠产生催眠作用的量效关系。方法用三种不同浓度合欢皮水煎液给予小鼠灌胃 ,就其对戊巴比妥钠的催眠作用所产生的影响进行比较。结果中、低浓度合欢皮水煎液可协同戊巴比妥钠缩短睡眠潜伏期及延长睡眠时间 (P <0 .0 1) ,高浓度合欢皮水煎液则对小白鼠有兴奋作用(P <0 .0 1)。结论合欢皮具有双向调节作用 ;提示合欢皮在临床用于失眠症时 ,似以较低剂量为佳。
ObjectiveTo study the effect of Cortex Albiziae solution pentobarbital-induced hypnosis in mice. MethodsThree doses of Cortex Albiziae solution were chosen to study their interaction with the hypnosis effect induced by pentobarbital sodium in mice.ResultsThe low and the middle doses of Cortex Albiziae could significantly shorten the latency of sleep and prolong the time of sleep in mice (P< 0.01 ). The high dose of Cortex Albiziae had significant stimulation (P< 0.01 ). ConclusionCortex Albiziae has double-direction adjustment effect, suggesting that the lower dose of Cortex Albiziae would be used in the treatment of insomnia.
出处
《河北医科大学学报》
CAS
2002年第4期216-217,共2页
Journal of Hebei Medical University
