摘要
目的 :观察蒙药荜茇的有效成分胡椒碱 (piperine)对实验性高胆固醇血症兔动脉粥样硬化形成的预防做用。方法 :新西兰兔 30只 ,根据血清总胆固醇水平分为对照组、预防组和粥样硬化组 ,每组 10只 ,实验期间 ,对照组 ,普通饲料 :预防组 ,普通饲料加胆固醇 1.2 %和 piperine0 .0 4 5 % ;粥样硬化组 ,普通饲料加胆固醇 1.2 %。 8周后处死动物 ,测定血脂水平和斑块面积。结果 :piperine降低实验性高胆固醇血症兔的血清总胆固醇 (TC)、低密度脂蛋白 -胆固醇 (L DL- C)、Apo B水平 ,对甘油三酯(TG)无明显影响。预防组和粥样硬化组动物胸主动脉斑块面积百分比分别为 0 .5 6 3± 0 .192和 0 .779± 0 .0 73内膜面积与中膜面积百分比分别为 0 .30 1± 0 .2 6 9和 0 .5 82± 0 .183,预防组斑块面积明显低于粥样硬化组 (P<0 .0 5 )。结论
Objective:To investigate the effects of piperine on experimental atherosclerosis in hypercholesterolemia rabbits.Methods:According to serum cholesterol level,3 dietary groups of New Zealand rabbits with 10 each were allocated as ①control(normal rabbits chow),②prevention group(1.2% high cholesterol diet+0.045% piperine),③atherosclerosis group(1.2% hiigh cholesterol)diet.After 9 weeks,all animals were killed to determine the serum lipids and the percent of thoracic aorta inner surface covered by plaque and the ratio of imtimal to medial cross-sectional areas in ascendant aorta. Results:piperine had no effect on TG level. The serum TC,LDL-c,ApoB level in piperine group was reduced than that of atherosclerosis group ( P <0.05). The aorta plaque areas in prevention group was significantly lower than that of atherosclerosis group ( P <0.05).Conclusions It is suggested that piperine could prevent the formation of aorta plaque and reduce the level of TC,LDL-c,ApoB in serum in the hypercholesterolemia rabbits.
出处
《中国民族医药杂志》
2002年第3期35-36,共2页
Journal of Medicine and Pharmacy of Chinese Minorities
