摘要
目的 :研制几丁糖万古霉素缓释放系统。方法 :几丁糖作为药物缓释载体是一种良好生物相容性的氨基多糖 ,通过分子间交联 ,溶剂蒸发 ,和模具分隔技术 ,制成药物的缓释放系统。同时测定几丁糖万古霉素DDS的抑菌作用。结果 :制备的几丁糖万古霉素DDS有效抑制金黄色葡萄球菌和大肠杆菌 1 0d。结论 :几丁糖与万古霉素能有效结合 ,并能缓慢释放万古霉素 ,体外达到较持久的抑菌作用。
Objective:To prepare the chitosan plate loaded vancocin as a Drug Sustained Delivery System(DSDS).Methods:Chitosan has proven to be a biocompatible aminopolysaccharide and a adjuvant for controlled release of pharmaceuticals.Combined cross linking,solvent evaporation,and a model cutting technique were used to prepare the chitosan plate as the DSDS of vancocin;meanwhile,antibacterial activities of vancocin released from the DSDS were detected.Result:The DSDS of the chitosan loaded vancocin effectively inhabited the two common causative organisms of Staphylococcus and Escherichia coli as long as 10 days in vitro.Conclusion:Chitosan is sufficiently combined with vancocin,and gradually releases it,which inhabits the organisms of Staphylococcus and Escherichia coli in vitro.
出处
《中国矫形外科杂志》
CAS
CSCD
2002年第7期694-695,共2页
Orthopedic Journal of China
关键词
几丁糖
万古霉素
缓释放系统
骨感染
Chitosan
Vancocin
Drug Delivery Sustained System(DSDS)
