摘要
目的 探讨胰岛素抵抗相关因素与胆囊结石发病风险之间的关系。方法 选择 2 4例糖耐量正常的胆囊结石患者和 2 8例健康对照者 ,测量其体重指数和腰臀比 ,并采空腹肘前静脉血测定血糖、糖化血红蛋白、胰岛素、C肽及血脂。采血后立即口服 75 g葡萄糖 ,2小时后再次采血测定血糖、胰岛素和 C肽。结果 结石组与对照组各项临床观测变量之间无显著性差异。单因素分析显示 ,各变量与胆囊结石发病风险间无明显联系。多因素分析显示 ,经控制混杂因素的影响后 ,胰岛素敏感指数及血甘油三酯可影响胆石症的发病风险。结论 胰岛素抵抗程度加重、甘油三酯增高均为胆囊结石发病的危险因素。
Objective To assess the association between the insulin resistance-related factors of and the risk of developing gallstones. Methods Body mass index(BMI), waist-to-hip circumference ratio(WHR), plasma glucose, glucosylated hemoglobin(HbA 1C), serum insulin, c-peptide and lipid concentrations were measured at fasting state in 24 gallstone patients with normal glucose tolerance and normal lipids and 28 healthy controls.The glucose,insulin and c-peptide were detected again at 2 hours after 75g glucose load.Results No significant difference in the clinical variables was seen between the gallstone group and control group. In univariate analysis, no variate was significantly associated with the risk of gallstones. In multivariate analysis, however, insulin sensitive index(ISI) and serum triglyceride concentration were found to be statistically significant risk factors for gallstones after adjusting for confounding factors.Conclusion The above results suggest that insulin resistance and increased serum triglyceride concentration act as risk factors for developing gallstones.
出处
《华西医科大学学报》
CSCD
北大核心
2002年第3期426-426,489,共2页
Journal of West China University of Medical Sciences
关键词
胆囊结石
胰岛素抵抗
多因素分析
Gallstone Insulin resistance Multivariate analysis
