摘要
目的 了解广防己肾脏毒性作用的毒理学特点。方法 分别给予正常大鼠 1、5和 10 g·kg-1广防己 ,观察其对肾脏形态和功能的影响。结果 给予 1g·kg-1广防己 8wk ,大鼠肾脏形态和功能无改变。给予 5g·kg-1广防己 4wk ,大鼠 2 4h尿蛋白增多并出现肾小管细胞变性、间质水肿等改变 ,但BUN和Scr正常。给予 10g·kg-1广防己 4wk ,大鼠BUN和Scr均显著升高 ,小管细胞变性更明显 ,并有肾间质轻度纤维化。结论 长期应用药典剂量广防己不造成明显的肾脏损害 。
AIM To study the nephrotoxicity of various doses of Guangfangji . METHODS Normal Wistar rats were given 1, 5 and 10 g·kg -1 of Guangfangji respectively. Renal pathology and function were observed. RESULTS Rats given 1 g·kg -1 of Guangfangji for 8 weeks showed normal renal function and histology Rats given 5 g·kg -1 of Guangfangji significantly increased 24 hour urinary protein excretion Tubular degeneration and interstitial edema was observed Blood urea nitrogen (BUN) and serum creactinine (Scr) remained in the normal range BUN and Scr increased significantly in the group given 10 g·kg -1 of Guangfangji for 4 weeks The tubulointerstitial abnormalities were more severe in the group given 5 g·kg -1 of Guangfangji CONCLUSION Longterm use of pharmacopoeial dose of Guangfangji shows no harm to the kidney.Renal injury may occur if relatively large dose of Guangfangji is given and the period of treatment using this drug is relatively longer
出处
《中国药理学通报》
CAS
CSCD
北大核心
2002年第3期285-287,共3页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助课题 No 3 990 0 193
