摘要
观察莲房原花青素(LSPC)对肝脂质过氧化损伤的作用。方法(1)体外大鼠肝匀浆温育,Fe2+、H2O2诱导引起肝脂质过氧化物(LPO)含量变化;(2)小鼠连续口服不同剂量LSPC7d后,一次性灌胃5%CCl4油溶液10ml/kgbw,24h后检测肝与血浆中超氧化物歧化酶(SOD)和脂质过氧化物(LPO)含量。结果:不同剂量LSPC能明显抑制体外肝组织LPO产生;口服中、低剂量LSPC则能显著降低CCl4中毒小鼠体内LPO含量,提高SOD活性。结论:适量LSPC具有抗氧化损伤作用,可能具有护肝功能。
To study the effects of procyanidins extract from the lotus seedpod(LSPC)on liver lipid peroxida-tion.Methods:(1)Liver homogenates were incubatedwi th Fe 2+ and H 2 O 2 invitro;(2)the mice after seven days sup-plementationof LSPC(100,200,400mg /kgbw.d),were treated with a single intragastric feeding of5%CCl 4 oil so-lution(10ml /kgbw).TheactivitiesofSODandthelevelo fLPOinliverandplasmaofCCl 4 intoxicmiceweredetermined affer 24h.Results:In vitro,LSPCcould significantly inhibit the forma tionof liver LPO.In vivo,LSPC(100,200mg /kg)evidently reduced the level of LPOan d increase the activities of SOD.Con clusion:It suggested that LSPCmight effectively protect liver fromthe i njury due to lipid antioxidation.
出处
《食品科学》
EI
CAS
CSCD
北大核心
2002年第7期98-100,共3页
Food Science
