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肢体挤压伤大鼠早期心电图及血清cTnI的变化

The changes of electrocardiogram and serum cardiac troponin I at the early stage of crush injury in rats
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摘要 目的观察挤压伤大鼠早期心电图的改变,并检测血清心肌肌钙蛋白I(cTnI)的变化。方法复制挤压伤大鼠动物模型,标准Ⅱ导联记录心电图变化,化学发光法检测血清cTnI水平。结果挤压伤后心电图ST段明显抬高,并持续24h,伤后6h血清cTnI则显著升高,并持续24h以上。结论肢体挤压伤早期存在心肌细胞的损伤。 Objective To observe the changes of electrocardiogram and serum cardiac troponin I at the early stage of severe crush injury in rats.Methods Crush injury was produced in Sprague-Dawley rats.The changes of electrocardiogram were recorded with the standard Ⅱ ,the serum levels of cardiac troponin I were studied by automated chemiluminescence assay.Results The ST segment elevated considerably after crush injury and lasted24h,the levels of serum cTnI were much higher than those of the control groupes after6h of injury.Conclusion Cardiomyocyte injury was induced in the early phase of crush injury.
作者 陈玉川 刘水平 郭薇
机构地区 中山医科大学法医病理学教研室
出处 《法医学杂志》 CAS CSCD 2002年第2期76-77,共2页 Journal of Forensic Medicine
关键词 挤压损伤 心肌肌钙蛋白 心电图 血清 大鼠 心肌损伤 crush injury cardiac troponin electrocardiogram.
分类号 R641 [医药卫生—外科学]
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参考文献6

  • 1Better OS. History of the crush syndrome:from the earthquakes of Messina,Sicily 1909 to Spitak,Amre-nia 1988[J].Am J Nephrol, 1997,17: 392-394.
  • 2刘水平,陈玉川,郭薇,成建定.挤压综合征大鼠血清酶浓度变化的初步研究[J].法医学杂志,2001,17(4):205-206. 被引量：2
  • 3Michaelson M. Crush injury and crush syndrome[J].World J Surg, 1992,16:899-903.
  • 4Apple FS. Tissue specificity of cardiac troponin I, ear-diac troponin T and creatine kinase-MB [J]. Clinic Chimica Acta, 1999,284:151-159.
  • 5Adams JE, Davila-Rroman VG,Bessey PQ,et al. Im proved detection of cardiac contusion with cardiac troponin I[J].Am Heart J. 1996,131:308-312.
  • 6Murphy JT, Horton JW,Purdue GF,et al. Evaluation of troponin-I as an indicator of cardiac dysfunc tion after thermal injury [J].J Trauma, 1998,45(4):700-704.

二级参考文献7

  • 1[1]Better OS. History of the crush syndrome:from the earthquakes of Messina,Sicily 1909 to Spitak,Amrenia 1988[J].Am J Nephrol,1997,17: 392- 394.
  • 2[2]Michaelson M. Crush injury and crush syndrome[J].World J Surg, 1992,16:899- 903.
  • 3[3]Odeh M.The role of reperfusion- induced injury in the pathogenesis of the crush syndrome[J].N Eng J Med,1991,324(20):1417- 1422.
  • 4[4]Abassi ZA,Hoffman A,Better OS,et al.Acute renal failure complicating muscle crush injury[J]. Semin Nephrol,1998,18(5):558- 565.
  • 5[5]Huang YS,Yang ZC,Yan BG,et al.Pathogenesis of early cardiac myocyte damage after severe burns[J].J Trauma,1999,46(3):428- 432.
  • 6[6]Murphy JT,Horton JW,Purdue GF,et al.Evaluation of troponin- I as an cardiac dysfunction after thermal injury.J Trauma,1998,45(4):700- 704.
  • 7[7]Horton JW,Garcia NM,White DJ,et al.Post- burn cardiac contractile function and biochemical markers of post- burn cardiac injury[J].J Am Coll Surg,1995,181:289- 298.

共引文献1

法医学杂志
2002年 第2期

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